Evidence map›Paper›PMID 26895218›Full record

ArticleTransplantation2017

Ambulatory Blood Pressure, Left Ventricular Hypertrophy, and Allograft Function in Children and Young Adults After Kidney Transplantation.

Gilad Hamdani, Edward J Nehus, Coral D Hanevold, Judith Sebestyen Van Sickle, Robert Woroniecki, Scott E Wenderfer, David K Hooper, Douglas Blowey, Amy Wilson, Bradley A Warady and 1 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Echocardiogram screening in pediatric dialysis and transplantation.Pediatric nephrology (Berlin, Germany) · 2023
    Review
  9. Article
  10. Hypertension in kidney transplant recipients.World journal of transplantation · 2022
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Management of dyslipidemia in pediatric renal transplant recipients.Pediatric nephrology (Berlin, Germany) · 2021
    Review
  16. Practical application of ABPM in the pediatric nephrology clinic.Pediatric nephrology (Berlin, Germany) · 2020
    Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Gilad Hamdani1 Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 2 Division of Pediatric Nephrology, Seattle Children's Hospital, Seattle, WA. 3 Division of Pediatric Nephrology, Children's Mercy Hospital, Kansas City, MO. 4 Division of Pediatric Nephrology, Stony Brook University Hospital, New York, NY. 5 Pediatric Renal Section, Texas Children's Hospital, Baylor College of Medicine, Houston, TX. 6 Division of Nephrology and Hypertension, J.W. Riley Hospital for Children, Indianapolis, IN.
Edward J Nehus
Coral D Hanevold
Judith Sebestyen Van Sickle
Robert Woroniecki
Scott E Wenderfer
David K Hooper
Douglas Blowey
Amy Wilson
Bradley A Warady
Mark M Mitsnefes
Apple (Israel) · ILCincinnati Children's Hospital Medical Center · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Cardiovascular Disease in Children with Chronic Kidney DiseaseK24DK090070 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI MITSNEFES, MARK M. · 2011 to 2015
$839k
NCATS NIH HHS UL1 TR001425NIDDK NIH HHS K24 DK090070
6 · The paper itself

Abstract

backgroundHypertension is a common complication and is an important risk factor for graft loss and adverse cardiovascular outcomes in pediatric kidney transplantation. Ambulatory blood pressure monitoring (ABPM) is the preferred method to characterize blood pressure status.

methodsWe conducted a retrospective review of a large cohort of children and young adults with kidney transplant to estimate the prevalence of abnormal ambulatory blood pressure (ABP), assess factors associated with abnormal ABP, and examine whether ambulatory hypertension is associated with worse allograft function and left ventricular hypertrophy (LVH).

resultsTwo hundred twenty-one patients had ABPM, and 142 patients had echocardiographic results available for analysis. One third of the patients had masked hypertension, 32% had LVH, and 38% had estimated glomerular filtration rate less than 60 mL/min per 1.73 m. African-American race/Hispanic ethnicity and requirement for more than 1 antihypertensive medication were independently associated with having masked hypertension. In a multivariate analysis, abnormal blood pressure (masked or sustained hypertension combined) was an independent predictor for LVH among patients not receiving antihypertensive treatment (P = 0.025). In a separate analysis, the use of antihypertensive medications was independently associated with worse allograft function (P = 0.002) although abnormal blood pressure was not a significant predictor.

conclusionsIn young kidney transplant recipients, elevated ABP is frequently unrecognized and undertreated. The high prevalence of abnormal ABP, including masked hypertension, and its association with LVH supports the case for routine ABPM and cardiac structure evaluation as the standard of care in these patients.

Indexed as

Blood PressureAdolescentAge FactorsAllograftsAntihypertensive AgentsBlood Pressure Monitoring, AmbulatoryChildChi-Square DistributionEchocardiographyFemaleHumansHypertensionHypertrophy, Left VentricularKidney TransplantationLogistic ModelsMaleAntihypertensive Agents

Identifiers

PMID26895218
PMCPMC4990501
OpenAlexW2280881771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.