ArticlePloS one2016
Confirmatory Factor Analysis and Differential Relationships of the Two Subdomains of Negative Symptoms in Chronically Ill Psychotic Patients.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Efficacy of adjunctive antidepressants in treating negative symptoms of schizophrenia: a systematic review and network meta-analysis.Psychological medicine · 2025Pooled it
- EPA guidance on assessment of negative symptoms in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2021Pooled it
- A Meta-Analysis of Social Skills Training and Related Interventions for Psychosis.Schizophrenia bulletin · 2018Pooled it
- Compensatory Cognitive Training for psychosis: Effects on negative symptom subdomains.Schizophrenia research · 2019Trial
- Confirmatory factor analysis of competing PANSS negative symptom models: data from OPTiMiSE first-episode schizophrenia study.BJPsych open · 2025Article
- Shedding light on the dynamic interplay of positive and negative symptoms of psychosis with Behavioral Tractography.NPJ digital medicine · 2025Article
- Moving from supported to independent living: what are the barriers and facilitators for individuals with psychosis?Social psychiatry and psychiatric epidemiology · 2024Article
- On the specificity of figurative language comprehension impairment in schizophrenia and its relation to cognitive skills but not psychopathological symptoms - Study on metaphor, humor and irony.Schizophrenia research. Cognition · 2024Article
- Turning the Spotlight on Apathy: Identification and Treatment in Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2023Article
- Negative symptoms in First-Episode Schizophrenia related to morphometric alterations in orbitofrontal and superior temporal cortex: the OPTiMiSE study.Psychological medicine · 2023Article
- A transdiagnostic approach to negative symptoms: exploring factor structure and negative symptoms in bipolar disorders.Frontiers in psychiatry · 2023Article
- Modifiable predictors of self-reported and performance-based functioning in individuals with schizophrenia-spectrum disorders and high levels of negative symptoms.Journal of psychiatric research · 2022Article
- Two Factors, Five Factors, or Both? External Validation Studies of Negative Symptom Dimensions in Schizophrenia.Schizophrenia bulletin · 2022Article
- What is the Best Latent Structure of Negative Symptoms in Schizophrenia? A Systematic Review.Schizophrenia bulletin open · 2021Article
- Recovery in Supported Accommodations: A Scoping Review and Synthesis of Interventions for People with Severe Mental Illness.Community mental health journal · 2020Article
- Differential improvement of negative-symptom subfactors after cognitive remediation in low-functioning individuals with schizophrenia.Schizophrenia research. Cognition · 2020Article
- Which levels of cognitive impairments and negative symptoms are related to functional deficits in schizophrenia?Journal of psychiatric research · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research suggests a two factor structure for negative symptoms in patients with psychotic disorders: social amotivation (SA) and expressive deficits (ED). Applying this two-factor structure in clinical settings may provide valuable information with regard to outcomes and to target treatments. We aimed to investigate 1) whether the factor structure is also supported in chronically ill patients with a psychotic disorder and 2) what the relationship is between these factors and functioning (overall functioning and living situation), depressive symptoms and quality of life. 1157 Patients with a psychotic disorder and a duration of illness of 5 years or more were included in the analysis (data selected from the Pharmacotherapy Monitoring Outcome Survey; PHAMOUS). A confirmatory factor analysis was performed using items of the Positive and Negative Syndrome Scale that were previously identified to reflect negative symptoms (N1-4, N6, G5, G7, G13, G16). Subsequently, regression analysis was performed on outcomes. The results confirmed the distinction between SA (N2, N4, G16) and ED (N1, N3, N6, G5, G7, G13) in chronically ill patients. Both factors were related to worse overall functioning as measured with the Health of the Nation Outcome Scales, ED was uniquely associated with residential living status. Higher scores for SA were associated with more depressive symptoms and worse quality of life. Thus, SA is most strongly related to level of social-emotional functioning, while ED are more related to living situation and thereby are indicative of level of everyday functioning. This subdivision may be useful for research purposes and be a valuable additional tool in clinical practice and treatment development.
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