ArticlePloS one2016
Immunisation With Immunodominant Linear B Cell Epitopes Vaccine of Manganese Transport Protein C Confers Protection against Staphylococcus aureus Infection.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- AntiPan: a genome-informed in silico pipeline for advancing subunit vaccine discovery against Staphylococcus aureus.Scientific reports · 2026Article
- Taming Superbugs: Current Progress and Challenges in Combating ESKAPE Pathogens.Pathogens (Basel, Switzerland) · 2025Review
- Surface displayed porcine epidemic diarrhea virus membrane epitopes onJournal of animal science and technology · 2025Article
- Epitope-Based Vaccines: The Next Generation of Promising Vaccines Against Bacterial Infection.Vaccines · 2025Review
- Protection of Mice Vaccinated with a New B Cell and T Cell Epitopes Cocktail from Staphylococcus aureus Challenge in Skin Infection Model.Current microbiology · 2025Article
- Computational prediction of multiple antigen epitopes.Bioinformatics (Oxford, England) · 2024Article
- Immunogenicity and Protective Capacity of Sugar ABC Transporter Substrate-Binding Protein againstVaccines · 2024Article
- B-Cell Epitope Predictions Using Computational Methods.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Characterization and Genomic Analysis of a New Phage InfectingInternational journal of molecular sciences · 2022Article
- Review
- EpiMix Based Novel Vaccine Candidate forInternational journal of peptide research and therapeutics · 2021Article
- ATP-binding cassette (ABC) import systems ofEmerging microbes & infections · 2020Review
- Selective substrate uptake: The role of ATP-binding cassette (ABC) importers in pathogenesis.Biochimica et biophysica acta. Biomembranes · 2018Review
- Protective effects of a nanoemulsion adjuvant vaccine (2C-Staph/NE) administered intranasally against invasiveRSC advances · 2018Article
- Protective humoral and CD4Scientific reports · 2018Article
- From Immunologically Archaic to Neoteric Glycovaccines.Vaccines · 2017Review
- Article
- An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction.Journal of immunology research · 2016Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccination strategies for Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA) infections have attracted much research attention. Recent efforts have been made to select manganese transport protein C, or manganese binding surface lipoprotein C (MntC), which is a metal ion associated with pathogen nutrition uptake, as potential candidates for an S. aureus vaccine. Although protective humoral immune responses to MntC are well-characterised, much less is known about detailed MntC-specific B cell epitope mapping and particularly epitope vaccines, which are less-time consuming and more convenient. In this study, we generated a recombinant protein rMntC which induced strong antibody response when used for immunisation with CFA/IFA adjuvant. On the basis of the results, linear B cell epitopes within MntC were finely mapped using a series of overlapping synthetic peptides. Further studies indicate that MntC113-136, MntC209-232, and MntC263-286 might be the original linear B-cell immune dominant epitope of MntC, furthermore, three-dimensional (3-d) crystal structure results indicate that the three immunodominant epitopes were displayed on the surface of the MntC antigen. On the basis of immunodominant MntC113-136, MntC209-232, and MntC263-286 peptides, the epitope vaccine for S. aureus induces a high antibody level which is biased to TH2 and provides effective immune protection and strong opsonophagocytic killing activity in vitro against MRSA infection. In summary, the study provides strong proof of the optimisation of MRSA B cell epitope vaccine designs and their use, which was based on the MntC antigen in the development of an MRSA vaccine.
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