ArticlePloS one2016
Fatigue in Multiple Sclerosis: Assessing Pontine Involvement Using Proton MR Spectroscopic Imaging.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Trial
- Vertical saccadic slowing is associated with fatigue in multiple sclerosis.Fatigue : biomedicine, health & behavior · 2026Article
- Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety.Neurology research international · 2024Article
- Brain Structural and Functional Alterations in Multiple Sclerosis-Related Fatigue: A Systematic Review.Neurology international · 2022Review
- Altered in vivo brain GABA and glutamate levels are associated with multiple sclerosis central fatigue.European journal of radiology · 2021Article
- Current Methods of Magnetic Resonance for Noninvasive Assessment of Molecular Aspects of Pathoetiology in Multiple Sclerosis.International journal of molecular sciences · 2020Review
- Phosphorus magnetic resonance spectroscopy and fatigue in multiple sclerosis.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Surveying sleep quality and fatigue in multiple sclerosis patients at a multiple sclerosis center in Kermanshah, Iran, in 2017.Neurobiology of sleep and circadian rhythms · 2020Article
- Characterizing Fatigue-Related White Matter Changes in MS: A Proton Magnetic Resonance Spectroscopy Study.Brain sciences · 2019Article
- Quantifying the Metabolic Signature of Multiple Sclerosis byFrontiers in neurology · 2019Review
- Functional brain connectivity of remembered fatigue or happiness in healthy adults: Use of arterial spin labeling.Journal of clinical and experimental neuropsychology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveThe underlying mechanism of fatigue in multiple sclerosis (MS) remains poorly understood. Our study investigates the involvement of the ascending reticular activating system (ARAS), originating in the pontine brainstem, in MS patients with symptoms of fatigue.
methodsFemale relapsing-remitting MS patients (n = 17) and controls (n = 15) underwent a magnetic resonance spectroscopic imaging protocol at 1.5T. Fatigue was assessed in every subject using the Fatigue Severity Scale (FSS). Using an FSS cut-off of 36, patients were categorized into a low (n = 9, 22 ± 10) or high (n = 10, 52 ± 6) fatigue group. The brain metabolites N-acetylaspartate (NAA) and total creatine (tCr) were measured from sixteen 5x5x10 mm3 spectroscopic imaging voxels in the rostral pons.
resultsMS patients with high fatigue had lower NAA/tCr concentration in the tegmental pons compared to control subjects. By using NAA and Cr values in the cerebellum for comparison, these NAA/tCr changes in the pons were driven by higher tCr concentration, and that these changes were focused in the WM regions. DISCUSSION/
conclusionSince there were no changes in NAA concentration, the increase in tCr may be suggestive of gliosis, or an imbalanced equilibrium of the creatine and phosphocreatine ratio in the pons of relapsing-remitting MS patients with fatigue.
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