Evidence map›Paper›PMID 26895003›Full record

ArticleEndocrine2016

Lack of significant association between type 2 diabetes mellitus with longitudinal change in diurnal salivary cortisol: the multiethnic study of atherosclerosis.

Elias K Spanakis, Xu Wang, Brisa N Sánchez, Ana V Diez Roux, Belinda L Needham, Gary S Wand, Teresa Seeman, Sherita Hill Golden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Glucocorticoid Receptor Signaling in Diabetes.International journal of molecular sciences · 2021
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. IN MY OWN WORDS: THE VALUE OF STORYTELLING TO SHAPE THE ACADEMIC MEDICINE JOURNEY.Transactions of the American Clinical and Climatological Association · 2018
    Article
  8. Article
  9. Diabetes in Cushing Disease.Current diabetes reports · 2017
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Elias K SpanakisDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument Street, Suite 333, Baltimore, MD, 21287, USA.
Xu WangDepartment of Epidemiology, Drexel University School of Public Health, Philadelphia, PA, USA.
Brisa N SánchezDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Ana V Diez RouxDepartment of Epidemiology, Drexel University School of Public Health, Philadelphia, PA, USA.
Belinda L NeedhamDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Gary S WandDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument Street, Suite 333, Baltimore, MD, 21287, USA.
Teresa SeemanDivision of Geriatrics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Sherita Hill GoldenDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument Street, Suite 333, Baltimore, MD, 21287, USA. sahill@jhmi.edu.
Johns Hopkins University · USDrexel University · USUniversity of Michigan–Ann Arbor · USUniversity of California, Los Angeles · US

Funding

Clinical Research&Epidemiology in Diabetes&EndocrinologyT32DK062707 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Wendy Lynet Bennett · 2002 to 2026
$7.3M
Stress, Gene-Environment Interaction and Cardiovascular DiseaseR01HL101161 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA, NEEDHAM, BELINDA L. · 2010 to 2013
$4.1M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
Tools for Measuring and Analyzing Cortisol Levels in Population Studies of HealthR21DA024273 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA · 2007 to 2010
$1.2M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
Enhancing immune reconstitution after implantation of postnatal allogeneic thymusR21HL095165 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CROOKS, GAY M · 2008 to 2009
$440k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
Adjunctive Use of Apyrase to Fibrinolytic TherapyR43HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2009 to 2009
$226k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READINGN01HC095169 · HC · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI DETRANO, ROBERT · 1999 to 2001
$124k
REGULATORY LIGHT CHAIN AND MYOCARDIAL CONTRACTIONF32HL010161 · NHLBI · UNIVERSITY OF WISCONSIN MADISON · PI HARRIS, SAMANTHA P · 1999 to 2000
$43k
NHLBI NIH HHS F32 HL010161NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL101161NIDA NIH HHS R21 DA024273NIDDK NIH HHS T32 DK062707
6 · The paper itself

Abstract

Cross-sectional association has been shown between type 2 diabetes and hypothalamic-pituitary-adrenal (HPA) axis dysregulation; however, the temporality of this association is unknown. Our aim was to determine if type 2 diabetes is associated with longitudinal change in daily cortisol curve features. We hypothesized that the presence of type 2 diabetes may lead to a more blunted and abnormal HPA axis profile over time, suggestive of increased HPA axis dysregulation. This was a longitudinal cohort study, including 580 community-dwelling individuals (mean age 63.7 ± 9.1 years; 52.8 % women) with (n = 90) and without (n = 490) type 2 diabetes who attended two MultiEthnic Study of Atherosclerosis Stress ancillary study exams separated by 6 years. Outcome measures that were collected were wake-up and bedtime cortisol, cortisol awakening response (CAR), total area under the curve (AUC), and early, late, and overall decline slopes. In univariate analyses, wake-up and AUC increased over 6 years more in persons with as compared to those without type 2 diabetes (11 vs. 7 % increase for wake-up and 17 vs. 11 % for AUC). The early decline slope became flatter over time with a greater flattening observed in diabetic compared to non-diabetic individuals (23 vs. 9 % flatter); however, the change was only statistically significant for wake-up cortisol (p-value: 0.03). Over time, while CAR was reduced more, late decline and overall decline became flatter, and bedtime cortisol increased less in those with as compared to those without type 2 diabetes, none of these changes were statistically significant in adjusted models. We did not identify any statistically significant change in cortisol curve features over 6 years by type 2 diabetes status.

Indexed as

AgedCircadian RhythmCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemLongitudinal StudiesMaleMiddle AgedPituitary-Adrenal SystemSalivaHydrocortisoneCortisolDiabetesEpidemiologyHPA axisStress

Identifiers

PMID26895003
PMCPMC4902713
OpenAlexW2275833291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.