ArticlePain2016
Quantitative sensory testing in classical trigeminal neuralgia-a blinded study in patients with and without concomitant persistent pain.
Article in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Diagnostic utility of trigeminocervical reflex and quantitative sensory testing in horses with trigeminal-mediated headshaking.Journal of veterinary internal medicine · 2026Article
- Quantitative Sensory Testing Identifies Altered Thermal and Pain Processing in Trigeminal Neuralgia.European journal of neurology · 2026Article
- Review
- Trigger zones in trigeminal neuralgia: clinical features, pathophysiological mechanisms, and therapeutic strategies.Frontiers in neurology · 2026Review
- Five-year prospective outcomes of medical management and microvascular decompression in trigeminal neuralgia.Journal of neurology · 2025Observational
- Pathogenesis, Diagnosis, and Management of Trigeminal Neuralgia: A Narrative Review.Journal of clinical medicine · 2025Review
- Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Conditioned Pain Modulation in Trigeminal Neuralgia Patients.Pain and therapy · 2024Article
- Mirror-Image Pain Update: Complex Interactions Between Central and Peripheral Mechanisms.Molecular neurobiology · 2024Review
- Review
- Long-term pain outcomes in trigeminal neuralgia patients with concomitant continuous pain: a comparison of first-time microvascular decompression and percutaneous balloon compression.Neurosurgical review · 2023Article
- Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale.Frontiers in neurology · 2023Article
- Sensory function in the faces of patients with facial palsy: A prospective observational study using quantitative sensory testing.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Variability in clinical and neurophysiological evaluation of pain development following acute spinal cord injury: a case report.Spinal cord series and cases · 2021Article
- Biomarkers in Temporomandibular Disorder and Trigeminal Neuralgia: A Conceptual Framework for Understanding Chronic Pain.Canadian journal of pain = Revue canadienne de la douleur · 2020Article
- Trigeminal Neuralgia: Basic and Clinical Aspects.Current neuropharmacology · 2020Review
- Dynamic of the somatosensory system in postherpetic neuralgia.Pain reports · 2018Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnostic criteria of the third International Classification of Headache Disorders state that there should be no neurological deficits in patients with classical trigeminal neuralgia (TN) at clinical examination. However, studies demonstrating sensory abnormalities at bedside examination in TN patients have questioned this. Our aim was to examine whether TN patients without sensory abnormalities at neurological examination have sensory abnormalities at quantitative sensory testing (QST) and whether there were any QST differences between TN with and without concomitant persistent pain. Thirty-six TN patients were investigated with the standardized QST protocol by the German Research Network on Neuropathic Pain. The investigators were blinded to presence of concomitant persistent pain and symptomatic side. Based on comparison to the German Research Network on Neuropathic Pain controls, z scores were calculated to process frequency analyses and Z-profiles. We found increased mechanical detection threshold on the symptomatic side (47.2% vs 0%, P = 0.008), asymptomatic side (33.3% vs 0%, P = 0.011), and hand (36% vs 0%, P < 0.001) in TN compared with controls. The Z-profiles demonstrated increased mechanical detection threshold on the symptomatic side compared with the asymptomatic side (-2.980 vs -2.166, P = 0.040). Thermal and mechanical hyperalgesia was detected bilaterally in the face and the hand. Trigeminal neuralgia patients with concomitant persistent pain tended to have higher mean z score values compared to TN with purely paroxysmal pain indicative of decreased detection thresholds. Trigeminal neuralgia patients with no sensory abnormalities at neurological examination had generalized subclinical hypoesthesia, which was more pronounced on the symptomatic side, and thermal and mechanical hyperalgesia. This could indicate pain-induced hypoesthesia and sensitization induced by central mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.