ArticlePLoS computational biology2016
Phenotypic Heterogeneity and the Evolution of Bacterial Life Cycles.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Selection in a growing colony biases results of mutation accumulation experiments.Scientific reports · 2022Article
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- Adaptation and phenotypic diversification of Bacillus thuringiensis biofilm are accompanied by fuzzy spreader morphotypes.NPJ biofilms and microbiomes · 2022Article
- Memory shapes microbial populations.PLoS computational biology · 2021Article
- Cryptic surface-associated multicellularity emerges through cell adhesion and its regulation.PLoS biology · 2021Article
- Links between S-adenosylmethionine and Agr-based quorum sensing for biofilm development in Listeria monocytogenes EGD-e.MicrobiologyOpen · 2020Article
- Mathematical model predicts anti-adhesion-antibiotic-debridement combination therapies can clear an antibiotic resistant infection.PLoS computational biology · 2019Article
- Coculturing Bacteria Leads to Reduced Phenotypic Heterogeneities.Applied and environmental microbiology · 2019Article
- The small non-coding RNA RsaE influences extracellular matrix composition in Staphylococcus epidermidis biofilm communities.PLoS pathogens · 2019Article
- Symbiont evolution during the free-living phase can improve host colonization.Microbiology (Reading, England) · 2019Article
- Selection for synchronized cell division in simple multicellular organisms.Journal of theoretical biology · 2018Article
- Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds.PLoS computational biology · 2018Article
- Bacteria as living patchy colloids: Phenotypic heterogeneity in surface adhesion.Science advances · 2018Article
- Cell adhesion and fluid flow jointly initiate genotype spatial distribution in biofilms.PLoS computational biology · 2018Article
- On the origin of biological construction, with a focus on multicellularity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Division of Labor, Bet Hedging, and the Evolution of Mixed Biofilm Investment Strategies.mBio · 2017Article
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Authors and funding
2 authors.
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Abstract
Most bacteria live in colonies, where they often express different cell types. The ecological significance of these cell types and their evolutionary origin are often unknown. Here, we study the evolution of cell differentiation in the context of surface colonization. We particularly focus on the evolution of a 'sticky' cell type that is required for surface attachment, but is costly to express. The sticky cells not only facilitate their own attachment, but also that of non-sticky cells. Using individual-based simulations, we show that surface colonization rapidly evolves and in most cases leads to phenotypic heterogeneity, in which sticky and non-sticky cells occur side by side on the surface. In the presence of regulation, cell differentiation leads to a remarkable set of bacterial life cycles, in which cells alternate between living in the liquid and living on the surface. The dominant life stage is formed by the surface-attached colony that shows many complex features: colonies reproduce via fission and by producing migratory propagules; cells inside the colony divide labour; and colonies can produce filaments to facilitate expansion. Overall, our model illustrates how the evolution of an adhesive cell type goes hand in hand with the evolution of complex bacterial life cycles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.