ArticlePloS one2016
Impact of Influenza on Outpatient Visits, Hospitalizations, and Deaths by Using a Time Series Poisson Generalized Additive Model.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- A Systematic Review of the Markers of Severity in Acute Respiratory Infections to Inform Primary Care Surveillance.Influenza and other respiratory viruses · 2025Pooled it
- Influenza-associated disease burden in mainland China: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Divergent surveillance needs and resource allocation for COVID-19 and influenza: insights from a community-based syndromic surveillance study in Shanghai (2024-2025).Frontiers in public health · 2026Article
- Excess Respiratory Hospitalisations Associated with Influenza, Respiratory Syncytial Virus and SARS-CoV-2 in Singapore from 2015 to 2023.Influenza and other respiratory viruses · 2025Article
- Excess multi-cause mortality linked to influenza virus infection in China, 2012-2021: a population-based study.Frontiers in public health · 2024Article
- Influenza-Associated Excess Mortality by Age, Sex, and Subtype/Lineage: Population-Based Time-Series Study With a Distributed-Lag Nonlinear Model.JMIR public health and surveillance · 2023Article
- Urban-rural disparities in the healthy ageing trajectory in China: a population-based study.BMC public health · 2022Article
- Does social participation decrease the risk of frailty? Impacts of diversity in frequency and types of social participation on frailty in middle-aged and older populations.BMC geriatrics · 2022Article
- Estimating excess septicaemia mortality and hospitalisation burden associated with influenza in Hong Kong, 1998 to 2019.Epidemiology and infection · 2022Article
- Burden of influenza-associated outpatient influenza-like illness consultations in China, 2006-2015: A population-based study.Influenza and other respiratory viruses · 2020Article
- Estimates of influenza-associated hospitalisations in tropical Singapore, 2010-2017: Higher burden estimated in more recent years.Influenza and other respiratory viruses · 2019Article
- Preliminary results of official influenza and acute respiratory infection surveillance in two towns of Burkina Faso, 2013-2015.BMC infectious diseases · 2018Article
- Using a hospital admission survey to estimate the burden of influenza-associated severe acute respiratory infection in one province of Cambodia-methods used and lessons learned.Influenza and other respiratory viruses · 2018Article
- Emergency Department demand associated with seasonal influenza, 2010 through 2014, New South Wales, Australia.Western Pacific surveillance and response journal : WPSARArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe disease burden associated with influenza in developing tropical and subtropical countries is poorly understood owing to the lack of a comprehensive disease surveillance system and information-exchange mechanisms. The impact of influenza on outpatient visits, hospital admissions, and deaths has not been fully demonstrated to date in south China.
methodsA time series Poisson generalized additive model was used to quantitatively assess influenza-like illness (ILI) and influenza disease burden by using influenza surveillance data in Zhuhai City from 2007 to 2009, combined with the outpatient, inpatient, and respiratory disease mortality data of the same period.
resultsThe influenza activity in Zhuhai City demonstrated a typical subtropical seasonal pattern; however, each influenza virus subtype showed a specific transmission variation. The weekly ILI case number and virus isolation rate had a very close positive correlation (r = 0.774, P < 0.0001). The impact of ILI and influenza on weekly outpatient visits was statistically significant (P < 0.05). We determined that 10.7% of outpatient visits were associated with ILI and 1.88% were associated with influenza. ILI also had a significant influence on the hospitalization rates (P < 0.05), but mainly in populations <25 years of age. No statistically significant effect of influenza on hospital admissions was found (P > 0.05). The impact of ILI on chronic obstructive pulmonary disease (COPD) was most significant (P < 0.05), with 33.1% of COPD-related deaths being attributable to ILI. The impact of influenza on the mortality rate requires further evaluation.
conclusionsILI is a feasible indicator of influenza activity. Both ILI and influenza have a large impact on outpatient visits. Although ILI affects the number of hospital admissions and deaths, we found no consistent influence of influenza, which requires further assessment.
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