Evidence map›Paper›PMID 26894855›Full record

ArticleOncotarget2016

Reduction of gastric cancer proliferation and invasion by miR-15a mediated suppression of Bmi-1 translation.

Changping Wu, Xiao Zheng, Xiaodong Li, Andrew Fesler, Wenwei Hu, Lujun Chen, Bin Xu, Qi Wang, Anthony Tong, Stephanie Burke and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer.Journal of personalized medicine · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Upregulation of theGenes & diseases · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Changping WuDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Xiao ZhengDepartment of Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Xiaodong LiDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Andrew FeslerTranslational Research Laboratory, Department of Pathology, Stony Brook University, Stony Brook, NY, USA.
Wenwei HuDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Lujun ChenDepartment of Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Bin XuDepartment of Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Qi WangDepartment of Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Anthony TongBioGenex Inc., Fremont, CA, USA.
Stephanie BurkeTranslational Research Laboratory, Department of Pathology, Stony Brook University, Stony Brook, NY, USA.
Jingfang JuTranslational Research Laboratory, Department of Pathology, Stony Brook University, Stony Brook, NY, USA.
Jingting JiangDepartment of Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Soochow University · CNStony Brook University · USBiogen (United States) · US

Funding

Roles of miR-129 in colorecal cancerR01CA197098 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI JU, JINGFANG · 2016 to 2020
$1.8M
Molecular Mechanism of miR-140 in Colon CancerR01CA155019 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI JU, JINGFANG · 2011 to 2014
$1.5M
Identification of post-transcriptionally regulated targets by TrIP-Chip/SeqR33CA147966 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI JU, JINGFANG · 2011 to 2013
$674k
NCI NIH HHS R01 CA155019NCI NIH HHS R01 CA197098NCI NIH HHS R33 CA147966
6 · The paper itself

Abstract

B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays important roles in gastric cancer, but the epigenetic regulatory mechanism by microRNA (miRNA) and the functional significance of Bmi-1 inhibition in gastric cancer remains elusive. In this study, we systematically investigated the functional roles of miRNA mediated Bmi-1 suppression in gastric cancer. Our results show that the expression of miR-15a is significantly reduced in gastric cancer and the protein expression levels of Bmi-1 are inversely correlated with miR-15a (P = 0.034) in gastric cancer patient samples. Functional studies revealed that ectopic expression of miR-15a decreased Bmi-1 in gastric cancer cell lines with reduced proliferation and tumor invasion. High levels of Bmi-1 in gastric cancer patients are significantly associated with better overall survival (P = 0.024) based on the Kaplan-Meier survival analysis.

Indexed as

Cell MovementCell ProliferationGene Expression Regulation, NeoplasticApoptosisBiomarkers, TumorFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMicroRNAsMiddle AgedNeoplasm InvasivenessNeoplasm StagingPolycomb Repressive Complex 1PrognosisBiomarkers, TumorBMI1 protein, humanMicroRNAsMIRN15 microRNA, humanPolycomb Repressive Complex 1Bmi-1gastric cancermiR-15asurvival

Identifiers

PMID26894855
PMCPMC4924733
OpenAlexW2276577415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.