ArticlePsychoneuroendocrinology2016
PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit.
Article in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Immune response to vaccination in adults with mental disorders: A systematic review.Journal of affective disorders · 2022Pooled it
- Stress and the Immune System: Insights From Psychoneuroimmunology.Physiological research · 2026Review
- Associations between immunosenescence and domain-specific cognition in the Health and Retirement Study Harmonized Cognitive Assessment Protocol.BMC biology · 2026Article
- Neuroimmune mechanisms in PTSD: inflammatory heterogeneity, circuit dysfunction, and biomarker-based subtypes.Molecular biology reports · 2026Review
- Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets.iScience · 2026Review
- Artificial intelligence and machine learning in immunosenescence: from biomarker discovery to clinical translation.Frontiers in aging · 2026Review
- MRI signature of brain age underlying post-traumatic stress disorder in World Trade Center responders.Translational psychiatry · 2025Article
- Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD.Brain, behavior, and immunity · 2025Article
- The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity.Immunity & ageing : I & A · 2025Article
- Research Progress on Inflammation and Immune Dysregulation in PTSD.Brain and behavior · 2025Review
- Social relationships and immune aging in early midlife: Evidence from the National Longitudinal Study of Adolescent to Adult Health.Brain, behavior, & immunity - health · 2025Article
- Revealing the effects of various immune cells in anorexia nervosa: Evidence from Mendelian randomization.Medicine · 2025Article
- Examining the relationship between biomarkers of immune aging and prevalent physical disability in the health and retirement study.Brain, behavior, and immunity · 2025Article
- Post traumatic stress disorder associated hypothalamic-pituitary-adrenal axis dysregulation and physical illness.Brain, behavior, & immunity - health · 2024Review
- Causal Relationship Between Post-Traumatic Stress Disorder and Immune Cell Traits: A Mendelian Randomization Study.Brain and behavior · 2024Article
- The embodiment of the neighborhood socioeconomic environment in the architecture of the immune system.PNAS nexus · 2024Article
- Innate and adaptive immune system consequences of post-traumatic stress disorder.Autonomic neuroscience : basic & clinical · 2024Review
- The association between incarceration and housing insecurity and advanced immune age during late life.Social science & medicine (1982) · 2024Article
- Socioeconomic status is negatively associated with immunosenescence but positively associated with inflammation among middle-aged women in Cebu, Philippines.Brain, behavior, and immunity · 2024Article
- Inflammation in Posttraumatic Stress Disorder: Dysregulation or Recalibration?Current neuropharmacology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundPsychosocial stress is thought to play a key role in the acceleration of immunological aging. This study investigated the relationship between lifetime and past-year history of post-traumatic stress disorder (PTSD) and the distribution of T cell phenotypes thought to be characteristic of immunological aging.
methodsData were from 85 individuals who participated in the community-based Detroit Neighborhood Health Study. Immune markers assessed included the CD4:CD8 ratio, the ratio of late-differentiated effector (CCR7-CD45RA+CD27-CD28-) to naïve (CCR7+CD45RA+CD27+CD28+) T cells, the percentage of KLRG1-expressing cells, and the percentage of CD57-expressing cells.
resultsIn models adjusted for age, gender, race/ethnicity, education, smoking status, and medication use, we found that past-year PTSD was associated with statistically significant differences in the CD8+ T cell population, including a higher ratio of late-differentiated effector to naïve T cells, a higher percentage of KLRG1+ cells, and a higher percentage of CD57+ cells. The percentage of CD57+ cells in the CD4 subset was also significantly higher and the CD4:CD8 ratio significantly lower among individuals who had experienced past-year PTSD. Lifetime PTSD was also associated with differences in several parameters of immune aging.
conclusionsPTSD is associated with an aged immune phenotype and should be evaluated as a potential catalyzer of accelerated immunological aging in future studies.
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