ArticleInternational journal of clinical oncology2016
Preoperative biliary drainage-related inflammation is associated with shorter survival in biliary tract cancer patients.
Article in International journal of clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Advances in Endoscopic Diagnosis and Management of Cholangiocarcinoma.Journal of clinical medicine · 2025Review
- Preoperative CT and MRI assessment of the longitudinal tumor extent of extrahepatic bile duct cancer after biliary drainageDiagnostic and interventional radiology (Ankara, Turkey) · 2024Article
- Pancreatic fistula and bleeding following choledochal cyst excision: Experience of two decades.Turkish journal of surgery · 2024Article
- Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma: When and how?World journal of gastrointestinal oncology · 2021Review
- Preoperative Cholangitis Affects Survival Outcome in Patients with Extrahepatic Bile Duct Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundAn association between inflammation and patient prognosis has been reported in various types of cancer. The aim of this study was to evaluate the influence of preoperative biliary drainage-related inflammation in patients with biliary tract cancer.
methodsThe clinical data of 97 patients who underwent surgery for extrahepatic bile duct cancer between February 2002 and September 2014 were analyzed, and the prognostic significance of tube-obstructive cholangitis after preoperative biliary drainage and pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) was evaluated.
resultsEighty-four (86.6 %) of the 97 patients underwent ERCP and preoperative biliary drainage. Tube-obstructive cholangitis occurred in 25 cases and post-ERCP pancreatitis in 8 cases. Collectively, 30 patients experienced preoperative biliary drainage-related inflammation consisting of tube-obstructive cholangitis and/or post-ERCP pancreatitis. Drainage-related inflammation was significant risk factor of postoperative complications (P = 0.006), and significant poor predictors of shorter progression-free survival (P = 0.003) and overall survival (OS; P = 0.006) after surgery. In multivariate analysis, drainage-related inflammation was an independent predictor of shorter OS (hazard ratio, 1.924; P = 0.037) after surgery.
conclusionPreoperative biliary drainage-related inflammation was an independent prognostic factor for shorter OS in biliary tract cancer patients.
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