Trial reportPloS one2016
Reliability of Task-Based fMRI for Preoperative Planning: A Test-Retest Study in Brain Tumor Patients and Healthy Controls.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Resting-State vs. Task-Based Functional Magnetic Resonance Imaging in Neurosurgical Planning: A Narrative Review of Clinical Applications.Biomedicines · 2026Review
- Emerging paradigms in connectome-guided neurosurgery for central nervous system tumors: a narrative review of structural and functional connectomics.Annals of medicine and surgery (2012) · 2026Review
- Test-retest reliability of resting-state functional magnetic resonance imaging during deep brain stimulation for Parkinson's disease.NeuroImage. Clinical · 2026Article
- Passive intraoperative motor fMRI under general anesthesia during open-craniotomy glioma surgery: a prospective technical feasibility study.Brain & spine · 2026Article
- Article
- Advancements in Imaging and Neurosurgical Techniques for Brain Tumor Resection: A Comprehensive Review.Cureus · 2024Review
- 7 T and beyond: toward a synergy between fMRI-based presurgical mapping at ultrahigh magnetic fields, AI, and robotic neurosurgery.European radiology experimental · 2024Review
- Increased task-relevant fMRI responsiveness in comatose cardiac arrest patients is associated with improved neurologic outcomes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- A comparison of fMRI presurgical mapping techniques with intraoperative brain mapping-based validation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Enhanced clinical task-based fMRI metrics through locally low-rank denoising of complex-valued data.The neuroradiology journal · 2023Article
- A New Functional Magnetic Resonance Imaging Localizer for Preoperative Language Mapping Using a Sentence Completion Task: Validity, Choice of Baseline Condition, and Test-Retest Reliability.Frontiers in human neuroscience · 2022Article
- Functional network alterations in young brain tumor patients with radiotherapy-induced memory impairments and vascular injury.Frontiers in neurology · 2022Article
- Tablet Technology for Writing and Drawing during Functional Magnetic Resonance Imaging: A Review.Sensors (Basel, Switzerland) · 2021Review
- Brain Mapping-Aided SupraTotal Resection (SpTR) of Brain Tumors: The Role of Brain Connectivity.Frontiers in oncology · 2021Review
- Distributed changes of the functional connectome in patients with glioblastoma.Scientific reports · 2020Article
- Test-retest of a phoria adaptation stimulus-induced functional MRI experiment.Journal of vision · 2020Article
- Optimizing data processing to improve the reproducibility of single-subject functional magnetic resonance imaging.Brain and behavior · 2020Article
- Test-Retest Reliability of Functional Magnetic Resonance Imaging Activation for a Vergence Eye Movement Task.Neuroscience bulletin · 2020Article
- Test-retest reliability of brain responses to risk-taking during the balloon analogue risk task.NeuroImage · 2020Article
- Optimizing Magnetoencephalographic Imaging Estimation of Language Lateralization for Simpler Language Tasks.Frontiers in human neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional magnetic resonance imaging (fMRI) continues to develop as a clinical tool for patients with brain cancer, offering data that may directly influence surgical decisions. Unfortunately, routine integration of preoperative fMRI has been limited by concerns about reliability. Many pertinent studies have been undertaken involving healthy controls, but work involving brain tumor patients has been limited. To develop fMRI fully as a clinical tool, it will be critical to examine these reliability issues among patients with brain tumors. The present work is the first to extensively characterize differences in activation map quality between brain tumor patients and healthy controls, including the effects of tumor grade and the chosen behavioral testing paradigm on reliability outcomes.
methodTest-retest data were collected for a group of low-grade (n = 6) and high-grade glioma (n = 6) patients, and for matched healthy controls (n = 12), who performed motor and language tasks during a single fMRI session. Reliability was characterized by the spatial overlap and displacement of brain activity clusters, BOLD signal stability, and the laterality index. Significance testing was performed to assess differences in reliability between the patients and controls, and low-grade and high-grade patients; as well as between different fMRI testing paradigms.
resultsThere were few significant differences in fMRI reliability measures between patients and controls. Reliability was significantly lower when comparing high-grade tumor patients to controls, or to low-grade tumor patients. The motor task produced more reliable activation patterns than the language tasks, as did the rhyming task in comparison to the phonemic fluency task.
conclusionIn low-grade glioma patients, fMRI data are as reliable as healthy control subjects. For high-grade glioma patients, further investigation is required to determine the underlying causes of reduced reliability. To maximize reliability outcomes, testing paradigms should be carefully selected to generate robust activation patterns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.