ReviewThe archives of bone and joint surgery2016
Giant Cell Tumor of Bone - An Overview.
Review in The archives of bone and joint surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed, 4 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- En-bloc resection for spinal giant cell tumors: superior outcomes-a comprehensive meta-analysis and trial sequential analysis.Neurosurgical review · 2025Pooled it
- Management of giant cell tumors of the distal radius: a systematic review and meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Pooled it
- The Role of Denosumab for Surgical Outcomes in Patients with Giant Cell Tumour of Bone: A Systematic Review.Current oncology (Toronto, Ont.) · 2021Pooled it
- Malignancy in Giant Cell Tumor of Bone: A Review of the Literature.Technology in cancer research & treatment · 2019Pooled it
- Efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone: a multicenter, phase Ib/II study.Nature communications · 2024Trial
- Video-Assisted Intralesional Curettage for Invasive Nonmalignant Giant Cell Tumors.Arthroscopy techniques · 2026Article
- Symptomatic Calcaneal Intraosseous Lipoma Mimicking Refractory Heel Pain: A Case Report and Review of the Literature.Clinical case reports · 2026Article
- Unnoticed Giant Cell Tumor of the Left Distal Tibia in a 52-Year-Old Male: A Rare Case Report.Journal of orthopaedic case reports · 2026Article
- Multicentric metachronous giant cell tumor of the femur: a rare case report and review of the literature.International journal of surgery case reports · 2026Article
- Intraosseous tumours of the knee.Skeletal radiology · 2026Review
- Reconstruction of Extensive Talar Bone Loss Using a Trabecular Metal Metaphyseal Cone Following Giant Cell Tumor Excision.Foot & ankle orthopaedics · 2026Article
- A Rare Case of Giant Cell tumor of Bone in Distal Tibia.Journal of orthopaedic case reports · 2026Article
- Secondary Malignant Transformation of Giant Cell Tumor of Bone Nine Years After Initial Curettage: A Case Report and Literature Review.Reports (MDPI) · 2026Article
- Giant Cell Tumor of the Metacarpal Treated with Non-Vascularized Bone Graft: A Case Report.Journal of orthopaedic case reports · 2026Article
- Campanacci stage and cortical destruction predict functional outcomes in giant cell tumor of bone.Irish journal of medical science · 2026Article
- Giant Cell Tumor of the Sacrum: A Narrative Review of Management Challenges and Modalities.Healthcare (Basel, Switzerland) · 2026Review
- Freezing nitrogen ethanol composite as an alternative to liquid nitrogen in giant cell tumor cryotherapy: a case report and literature review.International journal of surgery case reports · 2026Article
- Freezing nitrogen ethanol composite in treating giant cell tumor of bone: a clinical series of 32 patients.Journal of orthopaedic surgery and research · 2026Article
- New Insight in Pediatric Orthopedic Oncology: The Use of a Xeno-Hybrid Bone Substitute in Loss of Bone Tissue After Oncological Resections, a Case Series.Journal of clinical medicine · 2026Article
- Establishment and characterization of NCC-GCTB16-C1: novel patient-derived cell line of giant cell tumor of bone.Human cell · 2026Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear. It is characterized by a proliferation of mononuclear stromal cells and the presence of many multi- nucleated giant cells with homogenous distribution. There is no widely held consensus regarding the ideal treatment method selection. There are advocates of varying surgical techniques ranging from intra-lesional curettage to wide resection. As most giant cell tumors are benign and are located near a joint in young adults, several authors favor an intralesional approach that preserves anatomy of bone in lieu of resection. Although GCT is classified as a benign lesion, few patients develop progressive lung metastases with poor outcomes. Treatment is mainly surgical. Options of chemotherapy and radiotherapy are reserved for selected cases. Recent advances in the understanding of pathogenesis are essential to develop new treatments for this locally destructive primary bone tumor.
Indexed as
Identifiers
26894211PMC4733230W2225483069What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.