ArticleJournal of clinical and diagnostic research : JCDR2016
Histopathological and Immunohistochemical Evaluation of Meningiomas with Reference to Proliferative Markers p53 and Ki-67.
Article in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Brain invasion in meningiomas-clinical considerations and impact of neuropathological evaluation: a systematic review.Neuro-oncology · 2017Pooled it
- CD34 and p16 expression in central nervous system solitary fibrous tumors: an exploratory clinicopathologic study.Journal of neuro-oncology · 2026Article
- Double Staining Immunohistochemistry and Digital Pathology: Moving Towards Standardization of the Proliferative Index Evaluation in Meningiomas.Journal of personalized medicine · 2026Article
- Extracranial Extension of a Convexity Meningioma into the Temporal Fossa: A Rare Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- MRI-based multiregional radiomics for preoperative prediction of Ki-67 expression in meningiomas: a two-center study.Frontiers in neurology · 2025Article
- Contrast enhanced magnetic resonance imaging-based radiomics nomogram for preoperatively predicting expression status of Ki-67 in meningioma: a two-center study.Quantitative imaging in medicine and surgery · 2023Article
- Evaluation of P57, P53 and Ki67 Expression in Meningiomas.Journal of Korean Neurosurgical Society · 2022Article
- A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
- Grading meningiomas utilizing multiparametric MRI with inclusion of susceptibility weighted imaging and quantitative susceptibility mapping.Journal of neuroradiology = Journal de neuroradiologie · 2020Article
- Meningioma Tumor Microenvironment.Advances in experimental medicine and biology · 2020Review
- Histopathological Spectrum of Meningiomas with Emphasis on Prognostic Role of Ki67 Labelling Index.Iranian journal of pathology · 2020Article
- Long noncoding RNA PVT1 promotes hepatoblastoma cell proliferation through activating STAT3.Cancer management and research · 2019Article
- p53 and Cell Fate: Sensitizing Head and Neck Cancer Stem Cells to Chemotherapy.Critical reviews in oncogenesis · 2018Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMeningiomas are slow growing primary central nervous system (CNS) tumours attached to the duramater, which arise from the meningothelial cells of the arachnoid. Grading of meningioma based on histological findings assisted with supplementary immunohistochemical studies, predicts the prognosis of meningioma with good precision.
aimTo evaluate proliferative markers and correlate with various histological subtypes and grade. MATERIALS AND
methodsA total of 224 meningiomas, diagnosed between January1995 and October 2011were graded according to WHO 2007 criteria. Immunostaining for p53 and Ki-67 markers were performed on 100 cases.
resultsThere was female predominance. There were 194 Grade I, 24 Grade II and 6 Grade III meningiomas. Brain invasion noted in 18(8%) meningiomas predominantly in grade III followed by grade II. Recurrence was seen in 7 (3.1%) cases, most common in psammomatous followed by angiomatous meningioma. Immunostaining showed p53 positivity in 72.5% of grade I, 83.3% of grade II and all the cases of grade III tumours. Ki-67 Labelling Index (LI) consistently increased from grade I to grade III tumours.
conclusionp53 and Ki-67 LI correlated well with increasing histological grade and biological behaviour of meningioma.
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