Evidence map›Paper›PMID 26893942›Full record

ArticleClinical hypertension2016

The role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment.

Hyo-Sang Hwang, Kwang-Pil Ko, Myeong Gun Kim, Sihun Kim, Jeonggeun Moon, Wook Jin Chung, Mi Seung Shin, Seung Hwan Han

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  2. Article
  3. Role of dyslipidemia in early vascular aging syndromeTurkish journal of medical sciences · 2021
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hyo-Sang HwangDivision of Cardiovascular Disease, Department of Internal Medicine, Gachon University Gil Hospital, Medical Center, 1198 Kuwol-dong, Namdong-gu, 405-760 Incheon, South Korea.
Kwang-Pil KoDepartment of Preventive Medicine, Gachon University, Incheon, South Korea.
Myeong Gun KimDivision of Cardiovascular Disease, Department of Internal Medicine, Gachon University Gil Hospital, Medical Center, 1198 Kuwol-dong, Namdong-gu, 405-760 Incheon, South Korea.
Sihun KimDivision of Cardiovascular Disease, Department of Internal Medicine, Gachon University Gil Hospital, Medical Center, 1198 Kuwol-dong, Namdong-gu, 405-760 Incheon, South Korea.
Jeonggeun MoonDivision of Cardiovascular Disease, Department of Internal Medicine, Gachon University Gil Hospital, Medical Center, 1198 Kuwol-dong, Namdong-gu, 405-760 Incheon, South Korea.
Wook Jin ChungDivision of Cardiovascular Disease, Department of Internal Medicine, Gachon University Gil Hospital, Medical Center, 1198 Kuwol-dong, Namdong-gu, 405-760 Incheon, South Korea.
Mi Seung ShinDivision of Cardiovascular Disease, Department of Internal Medicine, Gachon University Gil Hospital, Medical Center, 1198 Kuwol-dong, Namdong-gu, 405-760 Incheon, South Korea.
Seung Hwan HanDivision of Cardiovascular Disease, Department of Internal Medicine, Gachon University Gil Hospital, Medical Center, 1198 Kuwol-dong, Namdong-gu, 405-760 Incheon, South Korea.
Deleted InstitutionGachon University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubjects with abnormal metabolic conditions had increased risk for cardiovascular disease. We investigated the role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment.

methodsA total 601 subjects (age 48.7 ± 11.8 years, male 46.2 %, hypertension 19.1 %) were enrolled. Major cardiovascular risk factors, metabolic conditions and parameters (pre-diabetes, diabetes mellitus, metabolic syndrome, fasting blood sugar (FBS), glycated hemoglobin), lipid profiles, hsCRP, and brachial ankle pulse wave velocity (baPWV) were measured.

resultsSubjects with metabolic syndrome (n = 200) had higher baPWV than in subjects without metabolic syndrome (n = 401) even after adjustments for age, sex and presence of hypertension (1435.9 ± 212.2 vs. 1336.5 ± 225.0 cm/sec, p < 0.001). The differences of baPWV among normal FBS, prediabetes and diabetes mellitus groups are significant (P for trend = 0.036) by multivariate analysis (adjustments for age, sex, office systolic blood pressure). Subjects with diabetes mellitus (n = 30) had higher baPWV than in subjects with normal FBS (n = 384, 1525 ± 267.1 vs. 1341.5 ± 224.1 cm/sec, P = 0.016 adjustments for age, sex, office systolic blood pressure). BaPWV in subjects with prediabetes (n = 187) was slightly higher, but not statistically significant than in subjects with normal FBS (P = 0.377). Of interest, FBS was one of the independent predictors for increased baPWV (β = 0.809, 95 % CI 0.222-1.397, p = 0.007) by multivariate analysis.

conclusionsSubjects with abnormal metabolic conditions have increased arterial stiffness independent of age and BP which may contribute to the development of cardiovascular disease.

Indexed as

Arterial stiffnessCardiovascular diseaseDiabetes mellitusMetabolic syndrome

Identifiers

PMID26893942
PMCPMC4756528
OpenAlexW2284510158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.