ArticleClinical hypertension2015
A psychosocial perspective of medication side effects, experiences, coping approaches and implications for adherence in hypertension management.
Article in Clinical hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Qualitative insights into the experiences and goals of people living with severe difficult-to-treat hypertension in Australia.BMC cardiovascular disorders · 2026Article
- Support needs of people living with hypertension in Ghana: the voices of the patients.BMC primary care · 2026Article
- Trends in Central Obesity Prevalence Among Adults With Hypertension in the United States, 2001-2023.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- PI3K/AKT/eNOS Modulation and Angiotensin II Suppression byACS omega · 2026Article
- Article
- Validation and reliability of the Thai version of the glasgow antipsychotic side-effect scale (GASS) in patients with schizophrenia.Frontiers in pharmacology · 2026Article
- Determinants of hypertension medication adherence among older adults in a resource-limited peri-urban setting, Ghana.Frontiers in public health · 2026Article
- The cascade of hypertension prevalence, awareness, treatment, and control in urban-poor communities in Accra, Ghana: a population-based household survey.BMC public health · 2025Article
- A bibliometric analysis and mapping of global research trends in antihypertensive medication adherence (1975-2024).The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Review
- Article
- Vasorelaxant effects and its mechanisms of the rhizome of Acorus gramineus on isolated rat thoracic aorta.Scientific reports · 2025Article
- The Immune-Enhancing Effects of aCurrent issues in molecular biology · 2025Article
- Pathways Linking Parental Social Support and Decision-Making Participation to Medication Adherence in Children With Epilepsy: The Moderating Role of Parental Anxiety.Depression and anxiety · 2025Article
- Hypotensive and Endothelium-Dependent Vasorelaxant Effects of Grayblue Spicebush Ethanol Extract in Rats.Foods (Basel, Switzerland) · 2023Article
- Interventions for Adherence Improvement in the Primary Prevention of Cardiovascular Diseases: Expert Consensus Statement.Korean circulation journal · 2022Review
- Realizing the Potential of the Patient Perspective.Patient preference and adherence · 2020Article
- Psycho-behavioural factors associated with medication adherence among male out-patients with hypertension in a Ghanaian hospital.PloS one · 2020Article
- Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system.Pharmacogenetics and genomics · 2019Article
- Barriers to and facilitators of hypertension management in Asmara, Eritrea: patients' perspectives.Journal of health, population, and nutrition · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study examined whether psychosocial variables influenced patients' perception and experience of side effects of their medicines, how they coped with these experiences and the impact on medication adherence behaviour.
methodsA hospital-based mixed methods study using quantitative and qualitative approaches was conducted with hypertensive patients. Participants were asked about side effects, medication adherence, common psychological symptoms and coping mechanisms with the aid of standard questionnaires and an interview guide.
resultsThe experiences of side effects-such as palpitations, frequent urination, recurrent bouts of hunger, erectile dysfunction, dizziness, cough, physical exhaustion-were categorized as no/low (39.75 %), moderate (53.0 %) and high (7.25 %). Significant relationships between depression (x (2) = 24.21, p < 0.0001), anxiety (x (2) = 42.33, p < 0.0001), stress (x (2) = 39.73, p < 0.0001) and side effects were observed. A logistic regression model using the adjusted results for this association is reported-depression [OR = 1.9 (1.03-3.57), p = 0.04], anxiety [OR = 1.5 (1.22-1.77), p ≤ 0.001] and stress [OR = 1.3 (1.02-1.71), p = 0.04]. Side effects significantly increased the probability of individuals to be non-adherent [OR = 4.84 (95 % CI 1.07-1.85), p = 0.04] with social factors, media influences and attitudes of primary care givers further explaining this relationship. Personal adoption of medication modifying strategies, espousing the use of complementary and alternative treatments and interventions made by clinicians were the main forms of coping with side effects. DISCUSSION: Results from this study show that, in addition to a biomedical approach, the experience of side effects has biological, social and psychological interrelations. The results offer more support for the need for a multi-disciplinary approach to healthcare where all forms of expertise are incorporated into health provision and patient care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.