ArticleSynlett : accounts and rapid communications in synthetic organic chemistry2013
Efficient, Traceless Semi-Synthesis of α-Synuclein Labeled with a Fluorophore/Thioamide FRET Pair.
Article in Synlett : accounts and rapid communications in synthetic organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye.Chemical science · 2024Article
- Combining non-canonical amino acid mutagenesis and native chemical ligation for multiply modifying proteins: A case study of α-synuclein post-translational modifications.Methods (San Diego, Calif.) · 2023Article
- Synthesis of Peptides and Proteins with Site-Specific Glutamate Arginylation.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Effects of Mutations and Post-Translational Modifications on α-Synuclein In Vitro Aggregation.Journal of molecular biology · 2022Review
- Incorporating thioamides into proteins by native chemical ligation.Methods in enzymology · 2021Article
- Effects of Glutamate Arginylation on α-Synuclein: Studying an Unusual Post-Translational Modification through Semisynthesis.Journal of the American Chemical Society · 2020Article
- Biosynthesis and Chemical Applications of Thioamides.ACS chemical biology · 2019Review
- Using a FRET Library with Multiple Probe Pairs To Drive Monte Carlo Simulations of α-Synuclein.Biophysical journal · 2018Article
- Chemoselective modifications for the traceless ligation of thioamide-containing peptides and proteins.Organic & biomolecular chemistry · 2016Article
- Electronic interactions of i, i + 1 dithioamides: increased fluorescence quenching and evidence for n-to-π* interactions.Chemical communications (Cambridge, England) · 2016Article
- Multiply labeling proteins for studies of folding and stability.Current opinion in chemical biology · 2015Review
- Mild and General Access to Diverse 1Advanced synthesis & catalysis · 2015Article
- Thioamide quenching of fluorescent probes through photoinduced electron transfer: mechanistic studies and applications.Journal of the American Chemical Society · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have shown that thioamides can be incorporated into proteins through semi-synthesis and used as probes to monitor structural changes. To date, our methods have required the presence of a cysteine at the peptide ligation site, which may not be present in the native peptide sequence. Here, we present a strategy for the semi-synthesis of thioproteins using homocysteine as a ligation point with subsequent masking as methionine, making the ligation "traceless."
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.