ArticleGenome biology and evolution2016
Evolution of a Heavy Metal Homeostasis/Resistance Island Reflects Increasing Copper Stress in Enterobacteria.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 106 citations in OpenAlex.
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- Genomic Epidemiology of FoodborneAntibiotics (Basel, Switzerland) · 2026Article
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- Poultry Proteus mirabilis in selected areas of Hunan, China: Resistance profiles and virulence genes.Poultry science · 2026Article
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- Comparison of the Presence of Heavy Metal Resistance Genes inMicroorganisms · 2025Article
- Systematic and synthetic biology insights into copper homeostasis in Escherichia coli.iScience · 2025Article
- Whole-genome sequencing characterization of silver-resistant bacteria from the outfall of wastewater treatment plants and effluent-receiving rivers.Applied and environmental microbiology · 2025Article
- Variation in accessory and horizontal gene transfer-associated genes drives lucinid endosymbiont diversity.FEMS microbiology ecology · 2025Article
- Multinuclear non-haem iron-dependent oxidative enzymes: landscape of their substrates, partner proteins and biosynthetic gene clusters.Microbial genomics · 2025Article
- Comparative genomic analysis of metal-tolerant bacteria reveals significant differences in metal adaptation strategies.Microbiology spectrum · 2025Article
- Augmenting Cr(VI) phytoremediation potential of Ricinus communis through rhizospheric crosstalk with multi stress tolerant plant growth promoting Bacillus altitudinis M1.World journal of microbiology & biotechnology · 2025Article
- The influence of trace metal supplementation on the presence of ceftriaxone resistance inMicrobiology spectrum · 2025Article
- Experimental evolution ofMicrobiology spectrum · 2025Article
- Exploring the genetic landscape of the Copper Homeostasis and Silver Resistance Island (CHASRI) in Salmonella enterica.PloS one · 2025Article
- Characterization ofFrontiers in microbiology · 2025Article
- Article
- A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Copper homeostasis in bacteria is challenged by periodic elevation of copper levels in the environment, arising from both natural sources and human inputs. Several mechanisms have evolved to efflux copper from bacterial cells, including thecus(copper sensing copper efflux system), andpco(plasmid-borne copper resistance system) systems. The genes belonging to these two systems can be physically clustered in a Copper Homeostasis and Silver Resistance Island (CHASRI) on both plasmids and chromosomes in Enterobacteria. Increasing use of copper in agricultural and industrial applications raises questions about the role of human activity in the evolution of novel copper resistance mechanisms. Here we present evidence that CHASRI emerged and diversified in response to copper deposition across aerobic and anaerobic environments. An analysis of diversification rates and a molecular clock model suggest that CHASRI experienced repeated episodes of elevated diversification that could correspond to peaks in human copper production. Phylogenetic analyses suggest that CHASRI originated in a relative ofEnterobacter cloacaeas the ultimate product of sequential assembly of several pre-existing two-gene modules. Once assembled, CHASRI dispersed via horizontal gene transfer within Enterobacteriaceae and also to certain members of Shewanellaceae, where the originalpcomodule was replaced by a divergentpcohomolog. Analyses of copper stress mitigation suggest that CHASRI confers increased resistance aerobically, anaerobically, and during shifts between aerobic and anaerobic environments, which could explain its persistence in facultative anaerobes and emergent enteric pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.