Evidence map›Paper›PMID 26892942›Full record

ArticleThe American journal of psychiatry2016

Neural Correlates of Irritability in Disruptive Mood Dysregulation and Bipolar Disorders.

Jillian Lee Wiggins, Melissa A Brotman, Nancy E Adleman, Pilyoung Kim, Allison H Oakes, Richard C Reynolds, Gang Chen, Daniel S Pine, Ellen Leibenluft

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03863288 (Dose-Response Relationship and Pharmacokinetics of Intranasal Oxytocin on Neural Impact in Youth With High Levels of Irritability), which is not on this map. Cited by 79 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 3 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03863288 phase1 / phase2terminatednot on this mapstarted 2022, after this paper: background citation

Dose-Response Relationship and Pharmacokinetics of Intranasal Oxytocin on Neural Impact in Youth With High Levels of Irritability

TypeinterventionalSponsorUniversity of NebraskaRan2022 to 2024Enrolled60ConditionsIrritable MoodArmsFunctional MRI (fMRI), Oxytocin Intranasal Spray 8 International Unit (8IU), Oxytocin intranasal spray 24 International Unit (24IU), Oxytocin intranasal spray 48 International Unit (48IU), Oxytocin intranasal spray 80 International Unit (80IU)
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023
    Pooled it
  3. Pooled it
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  7. An Exposure-Based Cognitive-Behavioral Therapy for Youth with Severe Irritability: Feasibility and Preliminary Efficacy.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Trial
  8. Article
  9. Review
  10. Observational
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  12. Article
  13. Observational
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  15. Article
  16. Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  17. Article
  18. Review
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  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jillian Lee WigginsFrom the Emotion and Development Branch and the Scientific and Statistical Computing Core, NIMH, Bethesda, Md.; the Department of Psychology, San Diego State University, San Diego; the Department of Psychology, Catholic University of America, Washington, D.C.; and the Department of Psychology, University of Denver, Denver.
Melissa A BrotmanFrom the Emotion and Development Branch and the Scientific and Statistical Computing Core, NIMH, Bethesda, Md.; the Department of Psychology, San Diego State University, San Diego; the Department of Psychology, Catholic University of America, Washington, D.C.; and the Department of Psychology, University of Denver, Denver.
Nancy E AdlemanFrom the Emotion and Development Branch and the Scientific and Statistical Computing Core, NIMH, Bethesda, Md.; the Department of Psychology, San Diego State University, San Diego; the Department of Psychology, Catholic University of America, Washington, D.C.; and the Department of Psychology, University of Denver, Denver.
Pilyoung KimFrom the Emotion and Development Branch and the Scientific and Statistical Computing Core, NIMH, Bethesda, Md.; the Department of Psychology, San Diego State University, San Diego; the Department of Psychology, Catholic University of America, Washington, D.C.; and the Department of Psychology, University of Denver, Denver.
Allison H OakesFrom the Emotion and Development Branch and the Scientific and Statistical Computing Core, NIMH, Bethesda, Md.; the Department of Psychology, San Diego State University, San Diego; the Department of Psychology, Catholic University of America, Washington, D.C.; and the Department of Psychology, University of Denver, Denver.
Richard C ReynoldsFrom the Emotion and Development Branch and the Scientific and Statistical Computing Core, NIMH, Bethesda, Md.; the Department of Psychology, San Diego State University, San Diego; the Department of Psychology, Catholic University of America, Washington, D.C.; and the Department of Psychology, University of Denver, Denver.
Gang ChenFrom the Emotion and Development Branch and the Scientific and Statistical Computing Core, NIMH, Bethesda, Md.; the Department of Psychology, San Diego State University, San Diego; the Department of Psychology, Catholic University of America, Washington, D.C.; and the Department of Psychology, University of Denver, Denver.
Daniel S PineFrom the Emotion and Development Branch and the Scientific and Statistical Computing Core, NIMH, Bethesda, Md.; the Department of Psychology, San Diego State University, San Diego; the Department of Psychology, Catholic University of America, Washington, D.C.; and the Department of Psychology, University of Denver, Denver.
Ellen LeibenluftFrom the Emotion and Development Branch and the Scientific and Statistical Computing Core, NIMH, Bethesda, Md.; the Department of Psychology, San Diego State University, San Diego; the Department of Psychology, Catholic University of America, Washington, D.C.; and the Department of Psychology, University of Denver, Denver.
University of America · US

Funding

The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
Scientific and Statistical Computing CoreZICMH002888 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI TAYLOR, PAUL · 2009 to 2025
$30.9M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZIAMH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2017
$10.8M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZ01MH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2000 to 2008
$3.1M
The Characterization And Treatment Of Children With Severe Mood DysregulationZ01MH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2002 to 2008
$2.8M
Intramural NIH HHS Z01 MH002778Intramural NIH HHS Z01 MH002786
6 · The paper itself

Abstract

objectiveBipolar disorder and disruptive mood dysregulation disorder (DMDD) are clinically and pathophysiologically distinct, yet irritability can be a clinical feature of both illnesses. The authors examine whether the neural mechanisms mediating irritability differ between bipolar disorder and DMDD, using a face emotion labeling paradigm because such labeling is deficient in both patient groups. The authors hypothesized that during face emotion labeling, irritability would be associated with dysfunctional activation in the amygdala and other temporal and prefrontal regions in both disorders, but that the nature of these associations would differ between DMDD and bipolar disorder.

methodDuring functional MRI acquisition, 71 youths (25 with DMDD, 24 with bipolar disorder, and 22 healthy youths) performed a labeling task with happy, fearful, and angry faces of varying emotional intensity.

resultsParticipants with DMDD and bipolar disorder showed similar levels of irritability and did not differ from each other or from healthy youths in face emotion labeling accuracy. Irritability correlated with amygdala activity across all intensities for all emotions in the DMDD group; such correlation was present in the bipolar disorder group only for fearful faces. In the ventral visual stream, associations between neural activity and irritability were found more consistently in the DMDD group than in the bipolar disorder group, especially in response to ambiguous angry faces.

conclusionsThese results suggest diagnostic specificity in the neural correlates of irritability, a symptom of both DMDD and bipolar disorder. Such evidence of distinct neural correlates suggests the need to evaluate different approaches to treating irritability in the two disorders.

Indexed as

Magnetic Resonance ImagingAdolescentAmygdalaArousalBipolar DisorderBrainBrain MappingChildDisruptive, Impulse Control, and Conduct DisordersEmotionsFacial RecognitionHumansIrritable MoodReference ValuesStatistics as TopicYoung Adult

Identifiers

PMID26892942
PMCPMC11193882
OpenAlexW2282514825

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.