ArticleThe American journal of psychiatry2016
Toward the Definition of a Bipolar Prodrome: Dimensional Predictors of Bipolar Spectrum Disorders in At-Risk Youths.
Article in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed, 211 citations in OpenAlex.
- Early Family Intervention for Youth at Risk for Bipolar Disorder: Psychosocial and Neural Mediators of Outcome.Current neuropharmacology · 2023Trial
- Effects of family intervention on psychosocial functioning and mood symptoms of youth at high risk for bipolar disorder.Journal of consulting and clinical psychology · 2022Trial
- Neural changes in youth at high risk for bipolar disorder undergoing family-focused therapy or psychoeducation.Bipolar disorders · 2021Trial
- Development and Open Trial of a Technology-Enhanced Family Intervention for Adolescents at Risk for Mood Disorders.Journal of affective disorders · 2021Trial
- Effects of Family-Focused Therapy vs Enhanced Usual Care for Symptomatic Youths at High Risk for Bipolar Disorder: A Randomized Clinical Trial.JAMA psychiatry · 2020Trial
- Early intervention for youth at high risk for bipolar disorder: A multisite randomized trial of family-focused treatment.Early intervention in psychiatry · 2019Trial
- Early intervention for adolescents at-risk for bipolar disorder: A pilot randomized trial of Interpersonal and Social Rhythm Therapy (IPSRT).Journal of affective disorders · 2018Trial
- A Pharmacologic Algorithm for Youth Who Are at High Risk for Bipolar Disorder.Journal of child and adolescent psychopharmacology · 2017Trial
- Towards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report.Bipolar disorders · 2026Review
- Identifying Mood Instability and Circadian Rest-Activity Patterns Using Digital Remote Monitoring and Actigraphy in Participants at Risk for Bipolar Disorder.Bipolar disorders · 2026Article
- Brainwide Structural Markers of Familial and Clinical Risk for Bipolar Disorder in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Dissociative Bipolar At-Risk Phenotype: Traumatic Burden and Subthreshold Affective Psychopathology in a Help-Seeking Youth Sample.Brain sciences · 2026Article
- Implicit learning across varying temporal scales in individuals with and without mood instability.Journal of affective disorders · 2026Article
- The Relationship Between Sleep Quality and Prodromal Symptoms in Euthymic Patients with Bipolar Disorder.Noro psikiyatri arsivi · 2026Article
- Catching the Storm Before It Breaks: Advancing Early Diagnosis and Intervention in Bipolar Disorder.Life (Basel, Switzerland) · 2025Review
- Application and efficacy of quetiapine in patients with high-risk factors for bipolar disorder: A randomized controlled trial.World journal of psychiatry · 2025Article
- The relationship between neurodevelopmental disorders (NDDs) and NLRP3 inflammasome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Predicting Diagnostic Progression to Schizophrenia or Bipolar Disorder via Machine Learning.JAMA psychiatry · 2025Article
- Article
- Predicting Conversion From Unipolar Depression to Bipolar Disorder and Schizophrenia: A 10-Year Retrospective Cohort Study on 12,182 Inpatients.Depression and anxiety · 2025Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe authors sought to assess dimensional symptomatic predictors of new-onset bipolar spectrum disorders in youths at familial risk of bipolar disorder ("at-risk" youths).
methodOffspring 6-18 years old of parents with bipolar I or II disorder (N=359) and community comparison offspring (N=220) were recruited. At baseline, 8.4% of the offspring of bipolar parents had a bipolar spectrum disorder. Over 8 years, 14.7% of offspring for whom follow-up data were available (44/299) developed a new-onset bipolar spectrum disorder (15 with bipolar I or II disorder). Measures collected at baseline and follow-up were reduced using factor analyses, and factors (both at baseline and at the visit prior to conversion or last contact) were assessed as predictors of new-onset bipolar spectrum disorders.
resultsRelative to comparison offspring, at-risk and bipolar offspring had higher baseline levels of anxiety/depression, inattention/disinhibition, externalizing, subsyndromal manic, and affective lability symptoms. The strongest predictors of new-onset bipolar spectrum disorders were baseline anxiety/depression, baseline and proximal affective lability, and proximal subsyndromal manic symptoms (p<0.05). While affective lability and anxiety/depression were elevated throughout follow-up in those who later developed a bipolar spectrum disorder, manic symptoms increased up to the point of conversion. A path analysis supported the hypothesis that affective lability at baseline predicts a new-onset bipolar spectrum disorder in part through increased manic symptoms at the visit prior to conversion; earlier parental age at mood disorder onset was also significantly associated with an increased risk of conversion. While youths without anxiety/depression, affective lability, and mania (and with a parent with older age at mood disorder onset) had a 2% predicted chance of conversion to a bipolar spectrum disorder, those with all risk factors had a 49% predicted chance of conversion.
conclusionsDimensional measures of anxiety/depression, affective lability, and mania are important predictors of new-onset bipolar spectrum disorders in at-risk youths. These symptoms emerged from among numerous other candidates, underscoring the potential clinical and research utility of these findings.
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