Trial reportThe British journal of psychiatry : the journal of mental science2016
Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial.
Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in The British journal of psychiatry : the journal of mental science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00928980 (The Clinical and Cost-effectiveness of Mindfulness Based Cognitive Therapy, Maintenance Antidepressant Medication and Its Combination in the Prevention of Relapse in Patients With Recurrent Depression), which is not on this map. Cited by 23 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
8.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Clinical and Cost-effectiveness of Mindfulness Based Cognitive Therapy, Maintenance Antidepressant Medication and Its Combination in the Prevention of Relapse in Patients With Recurrent Depression
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- An assessment of the reporting of tapering methods in antidepressant discontinuation trials using the TIDieR checklist.International journal of clinical pharmacy · 2023Pooled it
- Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Pooled it
- Managing Antidepressant Discontinuation: A Systematic Review.Annals of family medicine · 2019Pooled it
- Effects of discontinuation of chronic medication in primary care: a systematic review of deprescribing trials.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Pooled it
- Trial
- Factors associated with relapse and recurrence of major depressive disorder in patients starting mindfulness-based cognitive therapy.Depression and anxiety · 2022Trial
- Mindfulness and progressive muscle relaxation as standardized session-introduction in individual therapy: A randomized controlled trial.Journal of clinical psychology · 2019Trial
- Relapse/Recurrence Prevention in Major Depressive Disorder: 26-Month Follow-Up of Mindfulness-Based Cognitive Therapy Versus an Active Control.Behavior therapy · 2018Trial
- The Efficacy of a Group CBT Relapse Prevention Program for Remitted Anxiety Disorder Patients Who Discontinue Antidepressant Medication: A Randomized Controlled Trial.Psychotherapy and psychosomatics · 2018Trial
- Article
- Article
- Exploration of GP perspectives on deprescribing antidepressants: a qualitative study.BMJ open · 2021Article
- Article
- CBT and medication in depression (Review).Experimental and therapeutic medicine · 2020Review
- Cost-Utility Analysis of Mindfulness-Based Cognitive Therapy Versus Antidepressant Pharmacotherapy for Prevention of Depressive Relapse in a Canadian Context: Analyse coût-utilité de la thérapie cognitive basée sur la pleine conscience contre la pharmacothérapie antidépressive pour prévenir la rechute de la dépression en contexte canadien.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- The pursuit of euthymia.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Effectiveness of a brief psychological mindfulness-based intervention for the treatment of depression in primary care: study protocol for a randomized controlled clinical trial.BMC psychiatry · 2019Article
- Discontinuation of antidepressant medication in primary care supported by monitoring plus mindfulness-based cognitive therapy versus monitoring alone: design and protocol of a cluster randomized controlled trial.BMC family practice · 2019Article
- Preventive cognitive therapy could be a viable and effective addition to antidepressant medication in preventing relapse or recurrence in major depressive disorder.Evidence-based mental health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 2 countries.
Marloes J HuijbersMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands marloes.huijbers@radboudumc.nl.
Philip SpinhovenMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Jan SpijkerMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Henricus G RuhéMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Digna J F van SchaikMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Patricia van OppenMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Willem A NolenMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Johan OrmelMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Willem KuykenMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Gert Jan van der WiltMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Marc B J BlomMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Aart H ScheneMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
A RogierMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
T DondersMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Anne E M SpeckensMarloes J. Huijbers, MSc, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Philip Spinhoven, PhD, Institute of Psychology, Leiden University, Leiden and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Jan Spijker, PhD, MD, Pro Persona Nijmegen, Nijmegen, The Netherlands; Henricus G. Ruhé, PhD, MD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Digna J. F. van Schaik, PhD, MD, Patricia van Oppen, PhD, GGZ InGeest and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands, Willem A. Nolen, PhD, MD, Johan Ormel, PhD, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands; Willem Kuyken, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Gert Jan van der Wilt, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Marc B. J. Blom, PhD, MD, Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands; Aart H. Schene, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; A. Rogier T. Donders, PhD, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands; Anne E. M. Speckens, PhD, MD, Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLRadboud University Medical Center · NLGGZ inGeest · NLParnassia Groep · NLUniversity Medical Center Groningen · NLWarneford Hospital · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied.
aimsTo investigate whether MBCT with discontinuation of mADM is non-inferior to MBCT+mADM.
methodA multicentre randomised controlled non-inferiority trial (ClinicalTrials.gov:NCT00928980). Adults with recurrent depression in remission, using mADM for 6 months or longer (n= 249), were randomly allocated to either discontinue (n= 128) or continue (n= 121) mADM after MBCT. The primary outcome was depressive relapse/recurrence within 15 months. A confidence interval approach with a margin of 25% was used to test non-inferiority. Key secondary outcomes were time to relapse/recurrence and depression severity.
resultsThe difference in relapse/recurrence rates exceeded the non-inferiority margin and time to relapse/recurrence was significantly shorter after discontinuation of mADM. There were only minor differences in depression severity.
conclusionsOur findings suggest an increased risk of relapse/recurrence in patients withdrawing from mADM after MBCT.
Indexed as
Cognitive Behavioral TherapyMindfulnessAntidepressive AgentsCombined Modality TherapyFemaleHumansMajor Depressive DisorderMaleMiddle AgedRecurrenceSecondary PreventionTreatment OutcomeAntidepressive Agents
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT00928980ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.