Observational studyBMJ open2016
Is herpes zoster an additional complication in old age alongside comorbidity and multiple medications? Results of the post hoc analysis of the 12-month longitudinal prospective observational ARIZONA cohort study.
Observational study in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Memantine before Mastectomy Prevents Post-Surgery Pain: A Randomized, Blinded Clinical Trial in Surgical Patients.PloS one · 2016Trial
- Herpes Zoster and Frailty in Older Adults: a Systematic Review.Canadian geriatrics journal : CGJ · 2026Review
- Herpes Zoster in Aging Patients: Risk Factors and Prevention Strategies.International journal of general medicine · 2026Review
- Peripheral and central pathogenesis of postherpetic neuralgia.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Review
- The Incidence of Herpes Zoster Complications: A Systematic Literature Review.Infectious diseases and therapy · 2024Review
- Cost of illness of the vaccine-preventable diseases influenza, herpes zoster and pneumococcal disease in France.European journal of public health · 2024Article
- Greater functional connectivity between the ventral frontal cortex and occipital cortex in herpes zoster patients than post-herpetic neuralgia patients.The British journal of radiology · 2023Article
- Knowledge, attitudes, and practices of the United Arab Emirates population towards Herpes Zoster vaccination: A cross-sectional study.Human vaccines & immunotherapeutics · 2022Article
- Vaccination for quality of life: herpes-zoster vaccines.Aging clinical and experimental research · 2021Review
- Review
- Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia.The Journal of international medical research · 2020Article
- Topical Treatment of Localized Neuropathic Pain in the Elderly.Drugs & aging · 2020Review
- Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving.Journal of pain research · 2020Article
- MicroRNA And Circular RNA Expression In Affected Skin Of Patients With Postherpetic Neuralgia.Journal of pain research · 2019Article
- Intravenous infusion of lidocaine enhances the efficacy of conventional treatment of postherpetic neuralgia.Journal of pain research · 2019Article
- Measuring herpes zoster disease burden in São Paulo, Brazil: a clinico-epidemiological single-center study.Clinics (Sao Paulo, Brazil) · 2018Observational
- Herpes zoster chronification to postherpetic neuralgia induces brain activity and grey matter volume change.American journal of translational research · 2018Article
- Altered functional connectivity density in patients with herpes zoster and postherpetic neuralgia.Journal of pain research · 2018Article
- Localized neuropathic pain: an expert consensus on local treatments.Drug design, development and therapy · 2017Review
- Abnormal intrinsic brain functional network dynamics in patients with postherpetic neuralgia.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the burden of comorbidity, polypharmacy and herpes zoster (HZ), an infectious disease, and its main complication post-herpetic neuralgia (PHN) in young (50-70 years of age: 70-) and old (≥ 70 years of age: 70+) patients.
designPost hoc analysis of the results of the 12-month longitudinal prospective multicentre observational ARIZONA cohort study. SETTINGS AND
participantsThe study took place in primary care in France from 20 November 2006 to 12 September 2008. Overall, 644 general practitioners (GPs) collected data from 1358 patients aged 50 years or more with acute eruptive HZ. OUTCOME MEASURES: Presence of HZ-related pain or PHN (pain persisting >3 months) was documented at day 0 and at months 3, 6, and 12. To investigate HZ and PHN burden, pain, quality of life (QoL) and mood were self-assessed using validated questionnaires (Zoster Brief Pain Inventory, 12-item Short-Form health survey and Hospital Anxiety and Depression Scale, respectively).
resultsAs compared with younger patients, older patients more frequently presented with comorbidities, more frequently took analgesics and had poorer response on all questionnaires, indicating greater burden, at inclusion. Analgesics were more frequently prescribed to relieve acute pain or PHN in 70+ than 70- patients. Despite higher levels of medication prescription, poorer pain relief and poorer response to all questionnaires were reported in 70+ than 70- patients.
conclusionsOccurrence of HZ and progression to PHN adds extra burden on top of pharmacological treatment and impaired quality of life, especially in older patients who already have health problems to cope with in everyday life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.