ArticleNanoscale2016
DNA origami based Au-Ag-core-shell nanoparticle dimers with single-molecule SERS sensitivity.
Article in Nanoscale, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Single-Molecule Detection Concepts Enabled by DNA Origami.Micromachines · 2026Review
- Single-Molecule Detection of Optical Signals Using DNA-Based Plasmonic Nanostructures.Biosensors · 2025Review
- Radiation and DNA Origami Nanotechnology: Probing Structural Integrity at the Nanoscale.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Review
- Advancements in SERS: Revolutionizing Biomedical Analysis and Applications.Nanotheranostics · 2025Review
- Watching a Single Enzyme at Work Using Single-Molecule Surface-Enhanced Raman Scattering and DNA Origami-Based Plasmonic Antennas.ACS nano · 2024Article
- Experimental High-Resolution Observation of the Truncated Double-Icosahedron Structure: A Stable Twinned Shell in Alloyed Au-Ag Core@Shell Nanoparticles.Nano letters · 2024Article
- Dominant Analytical Techniques in DNA Nanotechnology for Various Applications.Analytical chemistry · 2024Article
- Multiplexing potential of NIR resonant and non-resonant Raman reporters for bio-imaging applications.The Analyst · 2023Article
- Developing an Electrochemically Reversible Switch for Modulating the Optical Signal of Gold Nanoparticles.Molecules (Basel, Switzerland) · 2023Article
- Synthesis of cuprous oxide/silver (CuRoyal Society open science · 2023Article
- Lab-on-a-DNA origami: nanoengineered single-molecule platforms.Chemical communications (Cambridge, England) · 2023Review
- Molecular states and spin crossover of hemin studied by DNA origami enabled single-molecule surface-enhanced Raman scattering.Nanoscale · 2022Article
- Article
- A Versatile DNA Origami-Based Plasmonic Nanoantenna for Label-Free Single-Molecule Surface-Enhanced Raman Spectroscopy.ACS nano · 2021Article
- A SERS Study of Charge Transfer Process in Au Nanorod-MBA@CuNanomaterials (Basel, Switzerland) · 2021Article
- DNA Origami-Enabled Plasmonic Sensing.The journal of physical chemistry. C, Nanomaterials and interfaces · 2021Review
- DNA Transformations for Diagnosis and Therapy.Advanced functional materials · 2021Review
- Raman Enhancement of Nanoparticle Dimers Self-Assembled Using DNA Origami Nanotriangles.Molecules (Basel, Switzerland) · 2021Article
- Recent advances in plasmonic nanocavities for single-molecule spectroscopy.Nanoscale advances · 2021Review
- DNA Origami-Templated Bimetallic Nanostar Assemblies for Ultra-Sensitive Detection of Dopamine.Frontiers in chemistry · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA origami nanostructures are a versatile tool to arrange metal nanostructures and other chemical entities with nanometer precision. In this way gold nanoparticle dimers with defined distance can be constructed, which can be exploited as novel substrates for surface enhanced Raman scattering (SERS). We have optimized the size, composition and arrangement of Au/Ag nanoparticles to create intense SERS hot spots, with Raman enhancement up to 10(10), which is sufficient to detect single molecules by Raman scattering. This is demonstrated using single dye molecules (TAMRA and Cy3) placed into the center of the nanoparticle dimers. In conjunction with the DNA origami nanostructures novel SERS substrates are created, which can in the future be applied to the SERS analysis of more complex biomolecular targets, whose position and conformation within the SERS hot spot can be precisely controlled.
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Registered trials
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