Evidence map›Paper›PMID 26892669›Full record

ArticleBMC cardiovascular disorders2016

Measurement of pulse wave velocity in normal ageing: comparison of Vicorder and magnetic resonance phase contrast imaging.

Jehill D Parikh, Kieren G Hollingsworth, Vijay Kunadian, Andrew Blamire, Guy A MacGowan

Registry-linked trialOpen access · goldAbstract readComparative Study
In one paragraph

Article in BMC cardiovascular disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01504828 (Cardiac Energetics and Function in Normal Human Ageing), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01504828 nacompletednot on this map

Cardiac Energetics and Function in Normal Human Ageing

TypeinterventionalSponsorNewcastle-upon-Tyne Hospitals NHS TrustRan2012 to 2015Enrolled135ConditionsLeft Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction, AgeingArmsRamipril
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

  1. Improved Ultrasonic Local Pulse Wave Velocity Estimation Via Optimal Time Fiduciary Point Combination and Time Delays Fitness.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
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  14. The landscape of aging.Science China. Life sciences · 2022
    Review
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  19. Review
  20. Chronic Kidney Disease and Pulse Wave Velocity: A Narrative Review.International journal of hypertension · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jehill D ParikhInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. Jehill.Parikh@newcastle.ac.uk.
Kieren G HollingsworthInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. kieren.hollingsworth@newcastle.ac.uk.
Vijay KunadianInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. vijay.kunadian@newcastle.ac.uk.
Andrew BlamireInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. a.m.blamire@newcastle.ac.uk.
Guy A MacGowanInstitute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. guy.macgowan@nuth.nhs.uk.
Newcastle University · GB

Funding

British Heart Foundation FS/11/89/29162
6 · The paper itself

Abstract

backgroundPulse wave velocity is an important measure of cardiovascular risk, and can be measured by several different techniques. We compared age-related changes in pulse wave velocity derived from carotid and femoral artery waveforms using the Vicorder device and descending thoracic aorta time velocity curves using phase contrast magnetic resonance imaging (MRI) in a group of normal healthy volunteers, without cardiovascular disease, aged between 20 and 79 years.

methodsEighty subjects underwent same-day measurements of Vicorder and MRI pulse wave velocity measurements.

resultsBoth Vicorder and MRI-based pulse wave velocity measurements were significantly increased with age (R = 0.59 and 0.57 respectively, both P < 0.0001). Vicorder and MRI pulse wave velocities were also significantly related to each other (R = 0.27, P < 0.05), and Bland Altman plots showed that on average Vicorder measurements were 1.6 m/s greater than MRI. In 5% of cases, agreement between the values of the two techniques were above and below 2 standard deviations, and these were at higher levels of pulse wave velocities. Multiple linear stepwise regression analysis confirmed highly significant relationships of both techniques to age (both P < 0.0001), and MRI was also significantly related to heart rate (P = 0.006) but Vicorder was not.

conclusionsBoth Vicorder and MRI perform similarly in detecting age-related changes in pulse wave velocity. Thus, the choice of using one or the other will depend on other aspects of the investigation, such as the need for portability favouring Vicorder, or need for additional cardiovascular imaging favouring MRI.

trial registrationClinicalTrials.Gov identifier NCT01504828.

Indexed as

AdultAgedAgingAorta, ThoracicCarotid ArteriesFemaleFemoral ArteryHeart RateHumansMagnetic Resonance ImagingMaleMiddle AgedPulse Wave AnalysisReproducibility of ResultsVascular StiffnessYoung Adult

Identifiers

PMID26892669
PMCPMC4759948
OpenAlexW2281970427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.