ArticleLangenbeck's archives of surgery2016
Visualizing fewer parathyroid glands may be associated with lower hypoparathyroidism following total thyroidectomy.
Article in Langenbeck's archives of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The outcomes of parathyroid gland autotransplantation during thyroid surgery: a systematic review, meta-analysis and trial sequential analysis.Endocrine · 2025Pooled it
- Parathyroid Allotransplantation: A Systematic Review.Medical sciences (Basel, Switzerland) · 2022Pooled it
- What are the real rates of temporary hypoparathyroidism following thyroidectomy? It is a matter of definition: a systematic review.Endocrine · 2021Pooled it
- A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy.Frontiers in oncology · 2020Pooled it
- Pooled it
- Impact of Intraoperative Interventions on Hypocalcemia Post-Total Thyroidectomy: A Meta-Analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialePooled it
- Indications and Complications of Total Thyroidectomy in the Management of Thyroid Diseases: A Five-Year Retrospective Study in a Greek Population.Acta medica academica · 2026Article
- Factors affecting the rates of incidental parathyroidectomy during thyroidectomy.Annals of the Royal College of Surgeons of England · 2024Article
- Predictors of hypocalcaemia and hypoparathyroidism in patients undergoing thyroidectomy for benign and malignant pathologies.Endocrine oncology (Bristol, England) · 2024Article
- A new histopathological location of parathyroid gland with high possibility of unintended parathyroidectomy.Gland surgery · 2023Article
- Indocyanine green (ICG) angiography-guided thyroidectomy: description of surgical technique.Frontiers in surgery · 2023Article
- Bilateral and Ipsilateral Central Neck Dissection in Total Thyroidectomy: a Long Term Comparison of Complications.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Near-infrared fluorescent imaging techniques for the detection and preservation of parathyroid glands during endocrine surgery.Innovative surgical sciences · 2022Article
- The long-term need for calcium supplementation after incidental parathyroidectomy.Journal of Taibah University Medical Sciences · 2022Article
- Association between number of parathyroid glands identified during total thyroidectomy and functional parathyroid preservation.Langenbeck's archives of surgery · 2022Article
- The utility of indocyanine green (ICG) for the identification and assessment of viability of the parathyroid glands during thyroidectomy.Updates in surgery · 2022Observational
- Thyroidectomy for Cancer: The Surgeon and the Parathyroid Glands Sparing.Journal of clinical medicine · 2021Article
- Development and validation of a new model for predicting hypocalcaemia after total thyroidectomy: the NuGra model.Langenbeck's archives of surgery · 2021Article
- Ultrasonic scalpel with knot tying protects parathyroid function for total thyroidectomy with central neck dissection.Gland surgery · 2020Article
- Parathyroid autotransplantation in thyroid surgery.Langenbeck's archives of surgery · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt remains uncertain whether the number of parathyroid glands (PGs) seen during extra-capsular dissection impacts short- and long-term hypoparathyroidism. Our study aimed to address this by analyzing patients who underwent total thyroidectomy for benign disease.
methodsConsecutive patients undergoing total thyroidectomy were analyzed. The extra-capsular dissection technique was performed throughout the study period. The number of PGs identified, auto-transplanted and found on excised specimen was recorded prospectively. The number of PGs in situ was equaled to four minus the number of PGs auto-transplanted and PGs found on specimen. Temporary hypoparathyroidism was defined as serum adjusted calcium <2.00 mol/L 24 h after surgery and/or need for oral supplements while protracted hypoparathyroidism meant subnormal PTH (<1.2 pmol/L) at 4-6 weeks and/or need for >6-week oral supplements. Permanent hypoparathyroidism was defined as need for oral supplements for ≥1 year.
resultsFive-hundred and sixty-nine patients were eligible for analysis. After adjusting for other significant parameters, greater number of PGs identified was an independent risk factor for temporary (p < 0.001) and protracted hypoparathyroidism (p = 0.007). Mean recovery time from protracted hypoparathyroidism for identifying ≤three PGs was significantly shorter than identifying all four PGs (2.8 vs. 7.8 months, p < 0.001). Chance of having all four PGs in situ decreased with greater number of PGs identified (p < 0.001).
conclusionsWhen the extra-capsular technique was adopted during total thyroidectomy, identifying fewer PGs in their orthotopic positions not only lowered risk of temporary and protracted hypoparathyroidism but also shortened recovery from protracted hypoparathyroidism.
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Registered trials
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