Evidence map›Paper›PMID 26892441›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2016

Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors.

Zehra Ordulu, Marisa R Nucci, Paola Dal Cin, Monica L Hollowell, Christopher N Otis, Jason L Hornick, Peter J Park, Tae-Min Kim, Bradley J Quade, Cynthia C Morton

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Review
  5. Article
  6. Article
  7. UTERINE FIBROIDS.Physiological reviews · 2025
    Review
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  9. Article
  10. Article
  11. Article
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  13. Article
  14. Review
  15. Article
  16. Surgical management of intravenous leiomyomatosis with intracardiac extension.Journal of vascular surgery cases and innovative techniques · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Zehra OrduluDepartments of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.
Marisa R NucciDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Paola Dal CinDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Monica L HollowellDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Christopher N OtisDepartment of Pathology, Baystate Medical Center, Springfield, MA, USA.
Jason L HornickDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Peter J ParkDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Tae-Min KimDepartments of Medical Informatics and Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Bradley J QuadeDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Cynthia C MortonDepartments of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USBaystate Medical Center · USCatholic University of Korea · KR

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6M
Genetic Studies of Uterine LeiomyomataR01HD060530 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI MORTON, CYNTHIA CASSON · 2010 to 2015
$1.8M
MOLECULAR AND CYTOGENETIC STUDIES OF UTERINE LEIOMYOMATAR01CA078895 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORTON, CYNTHIA CASSON · 1998 to 2002
$1.2M
NCI NIH HHS P30 CA006516NCI NIH HHS R01 CA078895NICHD NIH HHS R01 HD060530
6 · The paper itself

Abstract

Intravenous leiomyomatosis is an unusual smooth muscle neoplasm with quasi-malignant intravascular growth but a histologically banal appearance. Herein, we report expression and molecular cytogenetic analyses of a series of 12 intravenous leiomyomatosis cases to better understand the pathogenesis of intravenous leiomyomatosis. All cases were analyzed for the expression of HMGA2, MDM2, and CDK4 proteins by immunohistochemistry based on our previous finding of der(14)t(12;14)(q14.3;q24) in intravenous leiomyomatosis. Seven of 12 (58%) intravenous leiomyomatosis cases expressed HMGA2, and none expressed MDM2 or CDK4. Colocalization of hybridization signals for probes from the HMGA2 locus (12q14.3) and from 14q24 by interphase fluorescence in situ hybridization (FISH) was detected in a mean of 89.2% of nuclei in HMGA2-positive cases by immunohistochemistry, but in only 12.4% of nuclei in negative cases, indicating an association of HMGA2 expression and this chromosomal rearrangement (P=8.24 × 10(-10)). Four HMGA2-positive cases had greater than two HMGA2 hybridization signals per cell. No cases showed loss of a hybridization signal by interphase FISH for the frequently deleted region of 7q22 in uterine leiomyomata. One intravenous leiomyomatosis case analyzed by array comparative genomic hybridization revealed complex copy number variations. Finally, expression profiling was performed on three intravenous leiomyomatosis cases. Interestingly, hierarchical cluster analysis of the expression profiles revealed segregation of the intravenous leiomyomatosis cases with leiomyosarcoma rather than with myometrium, uterine leiomyoma of the usual histological type, or plexiform leiomyoma. These findings suggest that intravenous leiomyomatosis cases share some molecular cytogenetic characteristics with uterine leiomyoma, and expression profiles similar to that of leiomyosarcoma cases, further supporting their intermediate, quasi-malignant behavior.

Indexed as

TranscriptomeCytogenetic AnalysisFemaleGene Expression ProfilingHumansLeiomyomaLeiomyomatosisSmooth Muscle TumorUterine NeoplasmsVascular Neoplasms

Identifiers

PMID26892441
PMCPMC5891726
OpenAlexW2285035334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.