Evidence map›Paper›PMID 26892398›Full record

ArticleMagnetic resonance in medicine2017

Investigating tumor perfusion by hyperpolarized

Ilwoo Park, Cornelius von Morze, Janine M Lupo, Jan H Ardenkjaer-Larsen, Achuta Kadambi, Daniel B Vigneron, Sarah J Nelson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ilwoo ParkSurbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Cornelius von MorzeSurbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Janine M LupoSurbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Jan H Ardenkjaer-LarsenGE Healthcare, Brøndby, Denmark.
Achuta KadambiMedia Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Daniel B VigneronSurbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Sarah J NelsonSurbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.

Funding

Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Pavithra Viswanath · 2007 to 2026
$44.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
New Instrumentation and Techniques for Hyperpolarized Metabolic and Perfusion MRIR01EB013427 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2016
$2.8M
MR Metabolic Imaging of Response to Targeted Therapies in GBMR01CA154915 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NELSON, SARAH J., RONEN, SABRINA MIRIAM · 2011 to 2015
$2.7M
Molecular Imaging of Renal Transport and Metabolism using Hyperpolarized C-13 MRIK01DK099451 · NIDDK · WASHINGTON UNIVERSITY · PI VON MORZE, CORNELIUS · 2014 to 2018
$820k
Hyperpolarized C-13 MR Pulse Sequence Developments for Novel ContrastR00EB012064 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL · 2011 to 2013
$681k
RESPONSE TO THERAPY FOR PATIENTS WITH GLIOMA USING HYPERPOLARIZED C-13 PYRUVATER21CA170148 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NELSON, SARAH J. · 2012 to 2013
$631k
NCI NIH HHS P01 CA118816NCI NIH HHS R01 CA154915NCI NIH HHS R21 CA170148NCI NIH HHS T32 CA151022NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R00 EB012064NIBIB NIH HHS R01 EB013427NIDDK NIH HHS K01 DK099451
6 · The paper itself

Abstract

purposeDissolution dynamic nuclear polarization (DNP) enables the acquisition of

methodsDynamic

resultsDistinct HMCP perfusion characteristics were observed within the GBM tumors compared with contralateral normal brain tissue. The perfusion parameters obtained from the hyperpolarized HMCP data in tumor were strongly correlated with normalized peak height measured from the DSC images. The results from immunohistochemical analysis supported these findings by showing a high level of vascular staining for tumor that exhibited high levels of hyperpolarized HMCP signal.

conclusionThe results from this study have demonstrated that hyperpolarized HMCP data can be used as an indicator of tumor perfusion in an orthotopic xenograft model for GBM. Magn Reson Med 77:841-847, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

AnimalsBrain NeoplasmsCarbon IsotopesContrast MediaGadoliniumGlioblastomaHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleRatsRats, NudeCarbon IsotopesContrast MediaGadoliniumbrain tumordynamic nuclear polarizationgadolinium dynamic susceptibility contrast imaginghyperpolarized 13C perfusion MRI

Identifiers

PMID26892398
PMCPMC4991955

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.