Evidence map›Paper›PMID 26892160›Full record

ReviewWorld journal of urology2016

Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project.

A W Postema, T M De Reijke, O Ukimura, W Van den Bos, A R Azzouzi, E Barret, D Baumunk, A Blana, A Bossi, M Brausi and 31 more

Abstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Surveillance after Focal Therapy - a Comprehensive Review.Prostate cancer and prostatic diseases · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. [Focal therapy for prostate cancer].Der Urologe. Ausg. A · 2019
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors.

A W PostemaDepartments of Urology, AMC University Hospital, Amsterdam, The Netherlands. a.w.postema@amc.uva.nl.ORCID http://orcid.org/0000-0003-0629-871X
T M De ReijkeDepartments of Urology, AMC University Hospital, Amsterdam, The Netherlands.
O UkimuraUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
W Van den BosDepartments of Urology, AMC University Hospital, Amsterdam, The Netherlands.
A R AzzouziDepartment of Urology, Angers University Hospital, Angers, France.
E BarretDepartment of Urology, Institut Montsouris, Université Paris Descartes, Paris, France.
D BaumunkDepartment of Urology, Magdeburg University Medical Center, Magdeburg, Germany.
A BlanaDepartment of Urology, Fuerth Hospital, Fuerth, Germany.
A BossiDepartment of Radiation Oncology, Gustave Roussy Institute, Villejuif, France.
M BrausiDepartment of Urology, Ospedale Civile Ramazzini, Carpi, Italy.
J A ColemanDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
S CrouzetDepartment of Urology and Transplantation, Edouard Herriot Hospital, Lyon, France.
J Dominguez-EscrigDepartment of Urology, Instituto Valenciano de Oncología, Valencia, Spain.
S EggenerDepartment of Urology, University of Chicago, Chicago, IL, USA.
R GanzerDepartment of Urology, University of Leipzig, Leipzig, Germany.
S GhaiJoint Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada.
I S GillUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
R T GuptaDepartments of Radiology, Duke University Medical Center, Durham, NC, USA.
T O HenkelUrologische Praxis Dr. Henkel & Dr. Kahmann, Berlin, Germany.
M HohenfellnerDepartment of Urology, University of Heidelberg, Heidelberg, Germany.
J S JonesGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
F KahmannUrologische Praxis Dr. Henkel & Dr. Kahmann, Berlin, Germany.
C KastnerCamPARI Prostate Cancer Clinic, Cancer Directorate, Cambridge University Hospitals Trust, Cambridge, UK.
K U KöhrmannDepartment of Urology, Theresien Krankenhaus Mannheim, Mannheim, Germany.
G KovacsInterdisciplinary Brachytherapy Unit, University of Lübeck, Lübeck, Germany.
R MianoDivision of Urology, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
R J van MoorselaarDepartment of Urology, Free University Medical Centre, Amsterdam, The Netherlands.
N MottetDepartment of Urology, University Hospital St Etienne, Saint-Étienne, France.
L OsorioDepartment of Urology, Porto Hospital Centre, Porto, Portugal.
B R PietersDepartments of Radiation Oncology, AMC University Hospital, Amsterdam, The Netherlands.
T J PolascikDepartments of Surgery, Duke University Medical Center, Durham, NC, USA.
A R RastinehadDepartment of Urology, Hofstra North Shore-Lij, Hofstra University, Hempstead, NY, USA.
G SalomonMartini-Clinic Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
R Sanchez-SalasDepartment of Urology, Institut Montsouris, Université Paris Descartes, Paris, France.
M SchostakDepartment of Urology, Magdeburg University Medical Center, Magdeburg, Germany.
L SentkerUrologische Gemeinschaftspraxis, Sinsheim, Germany.
K J TayDepartments of Surgery, Duke University Medical Center, Durham, NC, USA.
I M Varkarakis2nd Department of Urology, Athens Medical University, University of Athens, Athens, Greece.
A VillersDepartment of Urology, Lille University Medical Center, Lille, France.
J WalzDepartment of Urology, Institut Paoli-Calmettes, Marseille, France.
J J De la RosetteDepartments of Urology, AMC University Hospital, Amsterdam, The Netherlands.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeTo reach standardized terminology in focal therapy (FT) for prostate cancer (PCa).

methodsA four-stage modified Delphi consensus project was undertaken among a panel of international experts in the field of FT for PCa. Data on terminology in FT was collected from the panel by three rounds of online questionnaires. During a face-to-face meeting on June 21, 2015, attended by 38 experts, all data from the online rounds were reviewed and recommendations for definitions were formulated.

resultsConsensus was attained on 23 of 27 topics; Targeted FT was defined as a lesion-based treatment strategy, treating all identified significant cancer foci; FT was generically defined as an anatomy-based (zonal) treatment strategy. Treatment failure due to the ablative energy inadequately destroying treated tissue is defined as ablation failure. In targeting failure the energy is not adequately applied to the tumor spatially and selection failure occurs when a patient was wrongfully selected for FT. No definition of biochemical recurrence can be recommended based on the current data. Important definitions for outcome measures are potency (minimum IIEF-5 score of 21), incontinence (new need for pads or leakage) and deterioration in urinary function (increase in IPSS >5 points). No agreement on the best quality of life tool was established, but UCLA-EPIC and EORTC-QLQ-30 were most commonly supported by the experts. A complete overview of statements is presented in the text.

conclusionFocal therapy is an emerging field of PCa therapeutics. Standardization of definitions helps to create comparable research results and facilitate clear communication in clinical practice.

Indexed as

Delphi TechniqueQuality of LifeCombined Modality TherapyHumansMaleProstate-Specific AntigenProstatic NeoplasmsSurveys and QuestionnairesProstate-Specific AntigenConsensusDefinitionsFocal therapyOutcomeProstate cancerStandardization

Identifiers

PMID26892160
PMCPMC5026990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.