ArticleCerebral cortex (New York, N.Y. : 1991)2016
Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed.
- Spatial connectivity for local cortical homogeneity.Research square · 2026Article
- Quantifying the compressibility of the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Spacetime concordance in the primate cortex.bioRxiv : the preprint server for biology · 2025Article
- Genetic contributions to brain criticality and its relationship with human cognitive functions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy.Clinical epigenetics · 2025Review
- Comparing reliability-based measures of functional connectivity between movie and rest: An ROI-based approach.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Heritability of functional gradients in the human subcortico-cortical connectivity.Communications biology · 2024Article
- Co-representation of Functional Brain Networks Is Shaped by Cortical Myeloarchitecture and Reveals Individual Behavioral Ability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dissociation of Reliability, Heritability, and Predictivity in Coarse- and Fine-Scale Functional Connectomes during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Charting the brain networks of impulsivity: Meta-analytic synthesis, functional connectivity modelling, and neurotransmitter associations.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Heritability of cognitive and emotion processing during functional MRI in a twin sample.Human brain mapping · 2024Article
- Genetic and environmental influence on resting state networks in young male and female adults: a cartographer mapping study.Human brain mapping · 2023Article
- Heritability of human "directed" functional connectome.Brain and behavior · 2023Article
- Environmental effects on brain functional networks in a juvenile twin population.Scientific reports · 2023Article
- Altered Resting-State Network in Adolescents with Problematic Internet Use.Journal of clinical medicine · 2022Article
- Emotional Brain Network Community Division Study Based on an Improved Immunogenetic Algorithm.Brain sciences · 2022Article
- The Role of Visual Experience in Individual Differences of Brain Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Shared genetic influences on resting-state functional networks of the brain.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
One of the grand challenges faced by neuroscience is to delineate the determinants of interindividual variation in the comprehensive structural and functional connection matrices that comprise the human connectome. At present, this endeavor appears most tractable at the macroanatomic scale, where intrinsic brain activity exhibits robust patterns of synchrony that recapitulate core functional circuits at the individual level. Here, we use a classical twin study design to examine the heritability of intrinsic functional network properties in 101 twin pairs, including network activity (i.e., variance of a network's specific temporal fluctuations) and internetwork coherence (i.e., correlation between networks' specific temporal fluctuations). Five of 7 networks exhibited significantly heritable (23.3-65.2%) network activity, 6 of the 21 internetwork coherences were significantly heritable (25.6-42.0%), and 11 of the 21 internetwork coherences were significantly influenced by common environmental factors (18.0-47.1%). These results suggest that the source of interindividual variation in functional connectome has a modular architecture: individual modules represented by intrinsic connectivity networks are genetic controlled, while environmental factors influence the interplays between the modules. This work further provides network-specific hypotheses for discovery of the specific genetic and environmental factors influencing functional specialization and integration of the human brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.