ArticleScientific reports2016
An embryonic atrazine exposure results in reproductive dysfunction in adult zebrafish and morphological alterations in their offspring.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 88 citations in OpenAlex.
- Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish.Toxicology · 2026Article
- Prenatal and postnatal atrazine-induced endocrine and ovarian chemical biotransformation protein disruption in offspring.Journal of the Endocrine Society · 2026Article
- Lipidomic and neurobehavioral alterations from developmental lead exposure in zebrafish.Journal of hazardous materials · 2026Article
- Therapeutic role of plant bioactive compounds in atrazine-mediated neurotoxicity.Advances in neurotoxicology · 2026Article
- Atrazine Induces Reproductive Toxicity in anBiomedicines · 2025Article
- Transcriptome Analysis Reveals Differential Gene Regulation in Ovarian Tissues of Anabas testudineus (Bloch, 1792) in Response to Insecticide, Monocrotophos.Marine biotechnology (New York, N.Y.) · 2025Article
- Quantification of Pesticides and In Vitro Effects of Water-Soluble Fractions of Agricultural Soils in South Africa.Archives of environmental contamination and toxicology · 2025Article
- Integrated Analysis of Neuroendocrine and Neurotransmission Pathways Following Developmental Atrazine Exposure in Zebrafish.International journal of molecular sciences · 2024Article
- Genetics, Epigenetics, and the Environment: Are Precision Medicine, Provider Compassion, and Social Justice Effective Public Health Measures to Mitigate Disease Risk and Severity?International journal of environmental research and public health · 2024Review
- Adverse developmental impacts in progeny of zebrafish exposed to the agricultural herbicide atrazine during embryogenesis.Environment international · 2023Article
- Atrazine and Diuron Effects on Survival, Embryo Development, and Behavior in Larvae and Adult Zebrafish.Frontiers in pharmacology · 2022Article
- Atresia of ovarian follicles in fishes, and implications and uses in aquaculture and fisheries.Journal of fish diseases · 2021Review
- Review
- Embryonic atrazine exposure and later in life behavioral and brain transcriptomic, epigenetic, and pathological alterations in adult male zebrafish.Cell biology and toxicology · 2021Article
- Agrochemicals in freshwater systems and their potential as endocrine disrupting chemicals: A South African context.Environmental pollution (Barking, Essex : 1987) · 2021Review
- Review:Frontiers in genetics · 2020Review
- Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring.PloS one · 2020Article
- The Effects of Maternal Atrazine Exposure and Swimming Training on Spatial Learning Memory and Hippocampal Morphology in Offspring Male Rats via PSD95/NR2B Signaling Pathway.Cellular and molecular neurobiology · 2019Article
- Effects of short-time exposure to atrazine on miRNA expression profiles in the gonad of common carp (Cyprinus carpio).BMC genomics · 2019Article
- Sediment pollution in an urban water supply lake in southern Brazil.Environmental monitoring and assessment · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The herbicide atrazine, a suspected endocrine disrupting chemical (EDC), frequently contaminates potable water supplies. Studies suggest alterations in the neuroendocrine system along the hypothalamus-pituitary-gonadal axis; however, most studies address either developmental, pubertal, or adulthood exposures, with few investigations regarding a developmental origins hypothesis. In this study, zebrafish were exposed to 0, 0.3, 3, or 30 parts per billion (ppb) atrazine through embryogenesis and then allowed to mature with no additional chemical exposure. Reproductive function, histopathology, hormone levels, offspring morphology, and the ovarian transcriptome were assessed. Embryonic atrazine exposure resulted in a significant increase in progesterone levels in the 3 and 30 ppb groups. A significant decrease in spawning and a significant increase in follicular atresia in the 30 ppb group were observed. In offspring, a decrease in the head length to body ratio in the 30 ppb group, along with a significant increase in head width to body ratio in the 0.3 and 3 ppb groups occurred. Transcriptomic alterations involved genes associated with endocrine system development and function, tissue development, and behavior. This study provides evidence to support atrazine as an EDC causing reproductive dysfunction and molecular alterations in adults exposed only during embryogenesis and morphological alterations in their offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.