Evidence map›Paper›PMID 26891899›Full record

ArticleScientific reports2016

Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis.

Jana Ninkovic, Ninkovic Jana, Vidhu Anand, Anand Vidhu, Raini Dutta, Dutta Raini, Li Zhang, Anuj Saluja, Jingjing Meng, Lisa Koodie and 5 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  4. Article
  5. Distinct Effects ofInternational journal of molecular sciences · 2021
    Article
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  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Jana Ninkovic
Ninkovic JanaDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455.
Vidhu Anand
Anand VidhuDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455.
Raini Dutta
Dutta RainiDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455.
Li ZhangDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455.
Anuj SalujaDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455.
Jingjing MengDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455.
Lisa Koodie
Koodie LisaDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455.
Santanu Banerjee
Banerjee SantanuDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455.
Sabita RoyDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455.
Roy Sabita
University of Minnesota · US

Funding

Training in PharmacoNeuroImmune Substance Abuse ResearchT32DA007097 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MOLITOR, THOMAS WILLIAM · 1985 to 2021
$13.1M
Opioid Abuse, opportunistic infection and NeuroAIDSR01DA012104 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROY, SABITA · 1999 to 2013
$3.7M
Morphine, HIV proteins, wound healing and InfectionR01DA022935 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2007 to 2011
$1.7M
Role of microRNAs in opioid drug abuse induced persistent Inflammation and HIV diR01DA031202 · NIDA · UNIVERSITY OF MINNESOTA · PI RAMAKRISHNAN, SUNDARAM, ROY, SABITA · 2011 to 2015
$1.7M
Mechanism underlying Morphine modulation of gut barrier function in the Context oR01DA034582 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2013 to 2017
$1.6M
Opioid Drug abuse in the context of opportunistic infection increases susceptibilK05DA033881 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2012 to 2016
$661k
NIDA NIH HHS K05 DA033881NIDA NIH HHS K05DA033881NIDA NIH HHS R01 DA012104NIDA NIH HHS R01 DA022935NIDA NIH HHS R01DA022935NIDA NIH HHS R01 DA031202NIDA NIH HHS R01DA031202NIDA NIH HHS R01 DA034582NIDA NIH HHS R01DA034582NIDA NIH HHS R01DA12104NIDA NIH HHS T32 DA007097
6 · The paper itself

Abstract

Opioid drug abusers have a greater susceptibility to gram positive (Gram (+)) bacterial infections. However, the mechanism underlying opioid modulation of Gram (+) versus Gram (-) bacterial clearance has not been investigated. In this study, we show that opioid treatment resulted in reduced phagocytosis of Gram (+), when compared to Gram (-) bacteria. We further established that LPS priming of chronic morphine treated macrophages leads to potentiated phagocytosis and killing of both Gram (+) and Gram (-) bacteria in a P-38 MAP kinase dependent signaling pathway. In contrast, LTA priming lead to inhibition of both phagocytosis and bacterial killing. This study demonstrates for the first time the differential effects of TLR4 and TLR2 agonists on morphine induced inhibition of phagocytosis. Our results suggest that the incidence and severity of secondary infections with Gram (+) bacteria would be higher in opioid abusers.

Indexed as

AnimalsGene ExpressionGram-Negative BacteriaGram-Positive BacteriaImmunomodulationLigandsLipopolysaccharidesMacrophagesMiceMice, KnockoutMicrobial ViabilityModels, BiologicalMorphinePhagocytosisTeichoic AcidsToll-Like Receptor 2LigandsLipopolysaccharideslipoteichoic acidMorphineTeichoic AcidsToll-Like Receptor 2Toll-Like Receptor 4

Identifiers

PMID26891899
PMCPMC4759540
OpenAlexW2337626822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.