Evidence map›Paper›PMID 26891839›Full record

Trial reportAIDS and behavior2016

HPTN 068: A Randomized Control Trial of a Conditional Cash Transfer to Reduce HIV Infection in Young Women in South Africa-Study Design and Baseline Results.

Audrey Pettifor, Catherine MacPhail, Amanda Selin, F Xavier Gómez-Olivé, Molly Rosenberg, Ryan G Wagner, Wonderful Mabuza, James P Hughes, Chirayath Suchindran, Estelle Piwowar-Manning and 9 more

Abstract readClinical Trial, Phase IIIRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Audrey PettiforDepartment of Epidemiology, University of North Carolina, McGavran Greenberg Building CB#7435, Chapel Hill, NC, 27599, USA. apettif@email.unc.edu.
Catherine MacPhailMRC/Wits Rural Public Health and Health Transitions Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Amanda SelinCarolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
F Xavier Gómez-OlivéMRC/Wits Rural Public Health and Health Transitions Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Molly RosenbergCenter for Population and Development Studies, Harvard University, Cambridge, MA, USA.
Ryan G WagnerMRC/Wits Rural Public Health and Health Transitions Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Wonderful MabuzaMRC/Wits Rural Public Health and Health Transitions Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
James P HughesSCHARP, Seattle, WA, USA.
Chirayath SuchindranCarolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
Estelle Piwowar-ManningHPTN Laboratory Center, Johns Hopkins University, Baltimore, MD, USA.
Jing WangSCHARP, Seattle, WA, USA.
Rhian TwineMRC/Wits Rural Public Health and Health Transitions Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Tamu DanielCarolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
Philip AndrewFHI360, Durham, NC, USA.
Oliver LaeyendeckerLaboratory of Immunoregulation, NIAID, NIH, Baltimore, MD, USA.
Yaw AgyeiHPTN Laboratory Center, Johns Hopkins University, Baltimore, MD, USA.
Stephen TollmanMRC/Wits Rural Public Health and Health Transitions Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Kathleen KahnMRC/Wits Rural Public Health and Health Transitions Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
HPTN 068 protocol team

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI MYRON Scott COHEN, Sinead Delany-Moretlwe · 2011 to 2026
$779.5M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
HIV Prevention trials Network (HPTN) Coordinating and Operations CenterU01AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI VERMUND, STEN H. · 2006 to 2010
$72.7M
University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit 2024 SupplementUM1AI069423 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, MINA CHRISTINE HOSSEINIPOUR · 2012 to 2026
$71.8M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Effects of Cash Transfer and Community Mobilization in Young South African WomenR01MH087118 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PETTIFOR, AUDREY · 2009 to 2013
$2.5M
NIAID NIH HHS P30 AI050410NIAID NIH HHS U01 AI068619NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068619NIAID NIH HHS UM1 AI069423NICHD NIH HHS P2C HD050924NICHD NIH HHS R24 HD050924NIMH NIH HHS R01 MH087118
6 · The paper itself

Abstract

Young women in South Africa are at high risk for HIV infection. Cash transfers offer promise to reduce HIV risk. We present the design and baseline results from HPTN 068, a phase III, individually randomized trial to assess the effect of a conditional cash transfer on HIV acquisition among South African young women. A total of 2533 young women were randomized to receive a monthly cash transfer conditional on school attendance or to a control group. A number of individual-, partner-, household- and school-level factors were associated with HIV and HSV-2 infection. After adjusting for age, all levels were associated with an increased odds of HIV infection with partner-level factors conveying the strongest association (aOR 3.05 95 % CI 1.84-5.06). Interventions like cash transfers that address structural factors such as schooling and poverty have the potential to reduce HIV risk in young women in South Africa.

Indexed as

MotivationRemunerationStudentsAdolescentAdultBlack PeopleEducationFemaleHerpes GenitalisHIV InfectionsHumansIncidenceOutcome Assessment, Health CarePovertyRiskSexual PartnersAdolescentsCash transfersEducationHIVHIV preventionSouth AfricaYoung women

Identifiers

PMID26891839
PMCPMC4990514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.