ArticleBMC musculoskeletal disorders2016
Dual-energy computed tomography has limited sensitivity for non-tophaceous gout: a comparison study with tophaceous gout.
Article in BMC musculoskeletal disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Clinical utility of Dual Energy Computed Tomography in gout: current concepts and applications.Acta bio-medica : Atenei Parmensis · 2020Pooled it
- Diagnostic accuracy of dual-energy CT in gout: a systematic review and meta-analysis.Skeletal radiology · 2018Pooled it
- Role of dual-energy CT in the diagnosis and follow-up of gout: systematic analysis of the literature.Clinical rheumatology · 2018Pooled it
- New urate depositions on dual-energy computed tomography in gouty arthritis during urate-lowering therapy.Rheumatology international · 2017Trial
- CT radiomics with transfer learning features for detecting DECT-positive periarticular monosodium urate crystal deposition: a single-center retrospective study.Frontiers in endocrinology · 2026Article
- Current and future role of CT and advanced CT applications in inflammatory arthritis in the clinic and trials.Skeletal radiology · 2025Review
- Imaging of gout: an atlas.Rheumatology advances in practice · 2025Review
- Updates on the Applications of Spectral Computed Tomography for Musculoskeletal Imaging.Diagnostics (Basel, Switzerland) · 2024Review
- Profiling of serum oxylipins identifies distinct spectrums and potential biomarkers in young people with very early onset gout.Rheumatology (Oxford, England) · 2023Article
- Gout.The New England journal of medicine · 2022Review
- Limitations of dual-energy CT in the detection of monosodium urate deposition in dense liquid tophi and calcified tophi.Skeletal radiology · 2021Article
- What Has Dual Energy CT Taught Us About Gout?Current rheumatology reports · 2021Review
- What is the diagnostic value of dual-energy computed tomography in patients with clinical diagnosis of gout?Advances in rheumatology (London, England) · 2021Article
- Diagnostic efficacy of joint ultrasonography, dual-energy computed tomography and minimally invasive arthroscopy on knee gouty arthritis, a comparative study.The British journal of radiology · 2021Article
- Case Series: Dual-Energy CT in Extra-Articular Manifestations of Gout: Main Teaching Point: Dual-energy CT is a valuable asset in the detection of extra-articular manifestations of gout.Journal of the Belgian Society of Radiology · 2020Article
- Dual-energy CT in the differentiation of crystal depositions of the wrist: does it have added value?Skeletal radiology · 2020Article
- Extra-abdominal dual-energy CT applications: a comprehensive overview.La Radiologia medica · 2020Review
- Diagnostic advances in synovial fluid analysis and radiographic identification for crystalline arthritis.Current opinion in rheumatology · 2019Review
- Combining non-contrast and dual-energy CT improves diagnosis of early gout.European radiology · 2019Article
- Recent developments in advanced imaging in gout.Therapeutic advances in musculoskeletal disease · 2019Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDual-energy computed tomography (DECT) is a new diagnostic tool for gout, but its sensitivity has not been established. Our goal was to assess the sensitivity of DECT for the detection of monosodium urate (MSU) deposits in non-tophaceous and tophaceous gout, both at the level of the patient and that of the individual joint or lesion.
methodsDECT was performed on 11 patients with crystal-proven non-tophaceous gout and 10 with tophaceous gout and included both the upper and lower extremities in 20/21 patients. DECT images were simultaneously acquired at 80 and 140 kV and then processed on a workstation with proprietary software using a two-material decomposition algorithm. MSU deposits were color coded as green by the software and fused onto grey-scale CT images. The number and location of these deposits was tallied independently by two DECT-trained radiologists blinded to the clinical characteristics of the patient. Sensitivity of DECT was defined as the proportion of patients with a confirmed diagnosis of gout which was correctly identified as such by the imaging technique. All patients provided informed consent to participate in this IRB-approved study.
resultsMSU deposits were detected by DECT in ≥1 joint area in 7/11 (64 %) patients with non-tophaceous gout, but were only detected in 3/12 (25 %) joints proven by aspiration to be affected with gout. Inclusion of the upper extremity joints in the scanning protocol did not improve sensitivity. All 10 patients with tophaceous gout had MSU deposits evident by DECT. The sensitivity of DECT for individual gouty erosions was assessed in 3 patients with extensive foot involvement. MSU deposits were detected by DECT within or immediately adjacent to 13/26 (50 %) erosions.
conclusionsA DECT protocol that includes all lower extremity joints has moderate sensitivity in non-tophaceous and high sensitivity in tophaceous gout. However, DECT has lower sensitivity when restricted to individual crystal-proven gouty joints in non-tophaceous disease or individual erosive lesions in tophaceous gout. The detection of MSU deposits by DECT relates to their size and density and the detection parameters of the DECT scanner and adjustment of the latter might improve sensitivity.
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