Evidence map›Paper›PMID 26891740›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2016

Ascending Aortic Aneurysm in Angiotensin II-Infused Mice: Formation, Progression, and the Role of Focal Dissections.

Bram Trachet, Alessandra Piersigilli, Rodrigo A Fraga-Silva, Lydia Aslanidou, Jessica Sordet-Dessimoz, Alberto Astolfo, Marco F M Stampanoni, Patrick Segers, Nikolaos Stergiopulos

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Article in Arteriosclerosis, thrombosis, and vascular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 95 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bram TrachetFrom the Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (B.T., R.A.F.-S., L.A., N.S.); IBiTech-bioMMeda, Ghent University-iMinds Medical IT, Ghent, Belgium (B.T., P.S.); School of Life Sciences, PTEC GE, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (A.P.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (A.P.); Histology Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (J.S.-D.); Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland (A.A., M.F.M.S.); and Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland (M.F.M.S.). bram.trachet@epfl.ch.
Alessandra PiersigilliFrom the Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (B.T., R.A.F.-S., L.A., N.S.); IBiTech-bioMMeda, Ghent University-iMinds Medical IT, Ghent, Belgium (B.T., P.S.); School of Life Sciences, PTEC GE, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (A.P.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (A.P.); Histology Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (J.S.-D.); Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland (A.A., M.F.M.S.); and Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland (M.F.M.S.).
Rodrigo A Fraga-SilvaFrom the Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (B.T., R.A.F.-S., L.A., N.S.); IBiTech-bioMMeda, Ghent University-iMinds Medical IT, Ghent, Belgium (B.T., P.S.); School of Life Sciences, PTEC GE, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (A.P.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (A.P.); Histology Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (J.S.-D.); Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland (A.A., M.F.M.S.); and Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland (M.F.M.S.).
Lydia AslanidouFrom the Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (B.T., R.A.F.-S., L.A., N.S.); IBiTech-bioMMeda, Ghent University-iMinds Medical IT, Ghent, Belgium (B.T., P.S.); School of Life Sciences, PTEC GE, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (A.P.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (A.P.); Histology Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (J.S.-D.); Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland (A.A., M.F.M.S.); and Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland (M.F.M.S.).
Jessica Sordet-DessimozFrom the Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (B.T., R.A.F.-S., L.A., N.S.); IBiTech-bioMMeda, Ghent University-iMinds Medical IT, Ghent, Belgium (B.T., P.S.); School of Life Sciences, PTEC GE, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (A.P.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (A.P.); Histology Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (J.S.-D.); Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland (A.A., M.F.M.S.); and Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland (M.F.M.S.).
Alberto AstolfoFrom the Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (B.T., R.A.F.-S., L.A., N.S.); IBiTech-bioMMeda, Ghent University-iMinds Medical IT, Ghent, Belgium (B.T., P.S.); School of Life Sciences, PTEC GE, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (A.P.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (A.P.); Histology Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (J.S.-D.); Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland (A.A., M.F.M.S.); and Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland (M.F.M.S.).
Marco F M StampanoniFrom the Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (B.T., R.A.F.-S., L.A., N.S.); IBiTech-bioMMeda, Ghent University-iMinds Medical IT, Ghent, Belgium (B.T., P.S.); School of Life Sciences, PTEC GE, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (A.P.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (A.P.); Histology Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (J.S.-D.); Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland (A.A., M.F.M.S.); and Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland (M.F.M.S.).
Patrick SegersFrom the Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (B.T., R.A.F.-S., L.A., N.S.); IBiTech-bioMMeda, Ghent University-iMinds Medical IT, Ghent, Belgium (B.T., P.S.); School of Life Sciences, PTEC GE, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (A.P.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (A.P.); Histology Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (J.S.-D.); Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland (A.A., M.F.M.S.); and Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland (M.F.M.S.).
Nikolaos StergiopulosFrom the Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (B.T., R.A.F.-S., L.A., N.S.); IBiTech-bioMMeda, Ghent University-iMinds Medical IT, Ghent, Belgium (B.T., P.S.); School of Life Sciences, PTEC GE, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (A.P.); Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland (A.P.); Histology Core Facility, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland (J.S.-D.); Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland (A.A., M.F.M.S.); and Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland (M.F.M.S.).
Paul Scherrer Institute · CHSwiss Light SourceUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo understand the anatomy and physiology of ascending aortic aneurysms in angiotensin II-infused ApoE(-/-) mice. APPROACH AND

resultsWe combined an extensive in vivo imaging protocol (high-frequency ultrasound and contrast-enhanced microcomputed tomography at baseline and after 3, 10, 18, and 28 days of angiotensin II infusion) with synchrotron-based ultrahigh resolution ex vivo imaging (phase contrast X-ray tomographic microscopy) in n=47 angiotensin II-infused mice and 6 controls. Aortic regurgitation increased significantly over time, as did the luminal volume of the ascending aorta. In the samples that were scanned ex vivo, we observed one or several focal dissections, with the largest located in the outer convex aspect of the ascending aorta. The volume of the dissections moderately correlated to the volume of the aneurysm as measured in vivo (r(2)=0.46). After 3 days of angiotensin II infusion, we found an interlaminar hematoma in 7/12 animals, which could be linked to an intimal tear. There was also a significant increase in single laminar ruptures, which may have facilitated a progressive enlargement of the focal dissections over time. At later time points, the hematoma was resorbed and the medial and adventitial thickness increased. Fatal transmural dissection occurred in 8/47 mice at an early stage of the disease, before adventita remodeling.

conclusionsWe visualized and quantified the dissections that lead to ascending aortic aneurysms in angiotensin II-infused mice and provided unique insight into the temporal evolution of these lesions.

Indexed as

Vascular RemodelingAngiotensin IIAnimalsAortaAortic Aneurysm, AbdominalAortic DissectionAortic RuptureAortic Valve InsufficiencyAortographyApolipoproteins EDilatation, PathologicDisease Models, AnimalDisease ProgressionElastic TissueMaleMice, Inbred C57BLAngiotensin IIApolipoproteins Eaortic aneurysmaortic dissectionascending aortacardiovascular imagingmouse models of human disease

Identifiers

PMID26891740
OpenAlexW2528675625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.