ReviewExpert review of molecular diagnostics2016
How recent advances in molecular tests could impact the diagnosis of pneumonia.
Review in Expert review of molecular diagnostics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990-2021: a systematic analysis from the Global Burden of Disease Study 2021.The Lancet. Infectious diseases · 2024Pooled it
- Emerging strategies for the noninvasive diagnosis of nosocomial pneumonia.Expert review of anti-infective therapy · 2019Pooled it
- Non-invasive molecular surveillance of drug-resistant bacterial and fungal pathogens in severe ICU pneumonia: a comparative study of nasopharyngeal swabs and BALF.Frontiers in microbiology · 2026Article
- No culture? No problem: Clinical utility and pitfalls of non-culture diagnostics for pneumococcal parapneumonic effusions.Frontiers in medicine · 2026Review
- Recent updates regarding the management and treatment of pneumonia in pediatric patients: a comprehensive review.Infection · 2025Review
- Impact of the microscopic quality of endotracheal aspirates on the performance of the Filmarray® pneumonia plus panel in intensive care unit patients with suspected lower respiratory tract infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Real World Evaluation of Next-Day Molecular Respiratory Infectious Disease Testing on Healthcare Resource Utilization and Costs.ClinicoEconomics and outcomes research : CEOR · 2025Article
- Clinical features, pathogens, and prognosis of immunocompromised host pneumonia in patients with malignancies.Frontiers in cellular and infection microbiology · 2025Article
- Clinical Characteristics and Microorganisms Isolated in Community-Acquired Pneumonia in the COVID-19 Period.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024Article
- The diagnostic utility of microscopic quality assessment of sputum samples in the era of rapid syndromic PCR testing.Microbiology spectrum · 2023Article
- Assessing the Utility of Multiplexed Polymerase Chain Reaction in Detecting Microorganisms Causing Infections in Critically ill Patients.Current microbiology · 2023Article
- Antimicrobial Stewardship Techniques for Critically Ill Patients with Pneumonia.Antibiotics (Basel, Switzerland) · 2023Review
- Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China.Emerging microbes & infections · 2022Article
- Evaluation of a multiplex PCR kit for detection of 17 respiratory pathogens in hospitalized patients.Journal of thoracic disease · 2022Article
- Utility of Polymerase Chain Reaction in Nasopharyngeal Swabs for Identifying Respiratory Bacteria Causing Community-Acquired Pneumonia.Microbiology spectrum · 2022Article
- Respiratory dysbiosis in cats with spontaneous allergic asthma.Frontiers in veterinary science · 2022Article
- Blood cultures and blood microbiota analysis as surrogates for bronchoalveolar lavage fluid analysis in dogs with bacterial pneumonia.BMC veterinary research · 2021Article
- Clinical and radiological diagnosis of non-SARS-CoV-2 viruses in the era of COVID-19 pandemic.Journal of medical virology · 2021Article
- Etiology and Prognosis of Pneumonia in Patients with Solid Tumors: A Prospective Cohort of Hospitalized Cases.The oncologist · 2020Article
- Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular diagnostic tests have been the single major development in pneumonia diagnostics over recent years. Nucleic acid detection tests (NATs) have greatly improved the ability to detect respiratory viruses and bacterial pathogens that do not normally colonize the respiratory tract. In contrast, NATs do not yet have an established role for diagnosing pneumonia caused by bacteria that commonly colonize the nasopharynx due to difficulties discriminating between pathogens and coincidental carriage strains. New approaches are needed to distinguish infection from colonization, such as through use of quantitative methods and identification of discriminating cut-off levels. The recent realization that the lung microbiome exists has provided new insights into the pathogenesis of pneumonia involving the interaction between multiple microorganisms. New developments in molecular diagnostics must account for this new paradigm.
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