ArticleAnesthesia and analgesia2016
2,3-Diphosphoglycerate Concentrations in Autologous Salvaged Versus Stored Red Blood Cells and in Surgical Patients After Transfusion.
Article in Anesthesia and analgesia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Efficacy and safety of intraoperative red blood cell salvage transfusion for spinal deformity surgery: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Storage of red blood cells in alkaline PAGGGM improves metabolism but has no effect on recovery after transfusion.Blood advances · 2022Trial
- Optimal 6-hour window for salvaged mediastinal blood retransfusion after cardiovascular surgery: an in vitro quality and safety analysis.Blood transfusion = Trasfusione del sangueTrial
- Indications for and strategies to reduce blood transfusion for craniosynostosis surgery: a narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- SvO₂ response to red blood cell transfusion in cardiovascular surgical icu patients: a retrospective observational study.Critical care (London, England) · 2026Observational
- Autologous transfusion of hemothoraces in resuscitation after thoracic trauma: a narrative review.Journal of trauma and injury · 2025Article
- Exploring Myths of Perioperative Autologous Red Blood Cell Salvage.Anesthesiology · 2025Article
- Neocyte-enriched blood does not provide a survival advantage for red cells when compared to conventional filtered blood.Vox sanguinis · 2025Article
- Intraoperative Cell Salvage in Oncologic Surgery: A Comprehensive Review.Journal of clinical medicine · 2025Review
- The Effect of Preoperative Anemia on Blood Transfusion Outcomes in Major Head and Neck Cancer Surgery.Cancers · 2025Article
- Assessing angiographic results of saline autotransfusion and thrombus aspiration in STEMI patients.Future cardiology · 2025Article
- Safety of intraoperative blood salvage in cancer surgery: what is new?Blood transfusion = Trasfusione del sangue · 2025Article
- Intraoperative Autologous Blood Transfusion in Aortic Surgery.Aorta (Stamford, Conn.) · 2024Article
- Association between routine cell salvage use for lower segment caesarean section and post-operative iron infusion and anemia.Archives of gynecology and obstetrics · 2024Article
- Pathogen reduced red blood cells as an alternative to irradiated and washed components with potential for up to 42 days storage.Blood transfusion = Trasfusione del sangue · 2024Article
- Article
- Impact of cold storage on the oxygenation and oxidation reactions of red blood cells.Frontiers in physiology · 2024Article
- Red Blood Cell Metabolism In Vivo and In Vitro.Metabolites · 2023Review
- Intraoperative use of cell saver devices decreases the rate of hyperlactatemia in patients undergoing cardiac surgery.Heliyon · 2023Article
- Use of Autotransfusion following Percutaneous Thrombectomy for Cardiogenic Shock Due to Pulmonary Embolism in a Single Session-A Case Report.Diagnostics (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundStored red blood cells (RBCs) are deficient in 2,3-diphosphoglycerate (2,3-DPG), but it is unclear how autologous salvaged blood (ASB) compares with stored blood and how rapidly 2,3-DPG levels return to normal after transfusion. Therefore, we compared levels of 2,3-DPG in stored versus ASB RBCs and in patients' blood after transfusion.
methodsTwenty-four patients undergoing multilevel spine fusion surgery were enrolled. We measured 2,3-DPG and the oxyhemoglobin dissociation curve (P50) in samples taken from the ASB and stored blood bags before transfusion and in blood samples drawn from patients before and after transfusion.
resultsThe mean storage duration for stored RBCs was 24 ± 8 days. Compared with fresh RBCs, stored RBCs had decreased 2,3-DPG levels (by approximately 90%; P < 0.0001) and a decreased P50 (by approximately 30%; P < 0.0001). However, ASB RBCs did not exhibit these changes. The mean 2,3-DPG concentration decreased by approximately 20% (P < 0.05) in postoperative blood sampled from patients who received 1 to 3 stored RBC units and by approximately 30% (P < 0.01) in those who received ≥4 stored RBC units. 2,3-DPG was unchanged in patients who received no stored blood or ASB alone. After surgery, 2,3-DPG levels recovered gradually over 3 postoperative days in patients who received stored RBCs.
conclusionsStored RBCs, but not ASB RBCs, have decreased levels of 2,3-DPG and a left-shift in the oxyhemoglobin dissociation curve. Postoperatively, 2,3-DPG levels remain below preoperative baseline levels for up to 3 postoperative days in patients who receive stored RBCs but are unchanged in those who receive only ASB RBCs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.