Evidence map›Paper›PMID 26891253›Full record

ArticleDiabetes/metabolism research and reviews2016

Prediabetes and diabetes among HIV-infected adults in Cameroon.

John Y Rhee, Tumi Divine Bahtila, Dennis Palmer, Pius Muffih Tih, Judith A Aberg, Derek LeRoith, Jennifer Jao

Open access · greenAbstract read
In one paragraph

Article in Diabetes/metabolism research and reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  17. Prevalence of and Risk Factors for Prediabetes in Patients Infected With HIV.Diabetes spectrum : a publication of the American Diabetes Association · 2018 · on this map
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

John Y RheeDepartment of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tumi Divine BahtilaCameroon Baptist Convention Health Services, Bamenda, Cameroon.
Dennis PalmerCameroon Baptist Convention Health Services, Bamenda, Cameroon.
Pius Muffih TihCameroon Baptist Convention Health Services, Bamenda, Cameroon.
Judith A AbergDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Derek LeRoithDepartment of Medicine, Division of Endocrinology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jennifer JaoDepartment of Medicine, Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cameroon Baptist Convention Health Services · CMIcahn School of Medicine at Mount Sinai · USMount Sinai Medical Center · US

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Shuibing Chen · 2015 to 2026
$27.7M
Metabolic Effects of In Utero Antiretrovirals on HIV Exposed Uninfected InfantsK23HD070760 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JAO, JENNIFER · 2012 to 2016
$647k
NICHD NIH HHS K23 HD070760NIDDK NIH HHS P30 DK020541
6 · The paper itself

Abstract

backgroundHuman immunodeficiency virus (HIV) and certain antiretrovirals are associated with diabetes. Few studies have examined the prevalence of and factors associated with diabetes among HIV-infected individuals on combination antiretroviral therapy (cART) in sub-Saharan Africa; some report prevalence estimates between 3.5-26.5% for diabetes in Cameroon and 20.2-43.5% for prediabetes in sub-Saharan Africa.

methodsIn a cross-sectional study, HIV-infected individuals (16-65 years old) were screened for diabetes using haemoglobin A1c (HbA1c ). We further categorized HbA1C as normoglycemia (HbA1c  < 5.7%), prediabetes (HbA1c 5.7-6.4%) or diabetes (HbA1c   ≥ 6.5%). Dysglycemia was defined as HbA1c  ≥ 5.7%. Logistic regression modelling was used to assess factors associated with having dysglycemia.

resultsOf 500 participants, 363 (72.6%) were female. Median age was 42.5 years [interquartile range (IQR): 36.5-49.5]. Nineteen patients (3.8%) had diabetes and 170 patients (34%) were classified as having prediabetes. One hundred nine (22%) had a CD4+ count <200 cells/mm(3) , and 464 (93%) had received >28 days of ART at time of screening. Median abdominal circumference for women was 79.5 cm (IQR: 75.5-85.3) and for men, 86.5 cm (IQR: 81.7-90.5). Adjusting for age, sex, socio-economic status, CD4 cell count, being on cART >28 days, body mass index, hypertension, history of hypertension, abdominal circumference and duration of HIV infection, larger abdominal circumference was associated with higher prevalence of prediabetes or diabetes (adjusted odds ratio = 1.07, 95% confidence interval: 1.03-1.11), while being on cART (adjusted odds ratio = 0.46, confidence interval: 0.22-0.99) was associated with lower prevalence.

conclusionsThere was a high prevalence of dysglycemia among Cameroonian HIV-infected adults. Larger abdominal circumference was associated with higher prevalence, while cART was associated with lower prevalence. Copyright © 2016 John Wiley & Sons, Ltd.

Indexed as

AdultBiomarkersCameroonCross-Sectional StudiesDiabetes MellitusFemaleGlycated HemoglobinHIV-1HIV InfectionsHumansMaleMiddle AgedPrediabetic StatePrevalencePrognosisBiomarkersGlycated Hemoglobinhemoglobin A1c protein, humanantiretroviral therapyCameroondiabetesHIVprevalence

Identifiers

PMID26891253
PMCPMC5087795
OpenAlexW2520408419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.