ArticleAmerican journal of nephrology2016
Mortality Outcomes of Patients with Chronic Kidney Disease and Chronic Obstructive Pulmonary Disease.
Article in American journal of nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of sleep disturbances in individuals with comorbid diabetes and chronic kidney disease: a systematic review.Sleep & breathing = Schlaf & Atmung · 2025Pooled it
- Consequences of chronic kidney disease in chronic obstructive pulmonary disease.Respiratory research · 2019Trial
- Artificial intelligence in nephrology: predicting CKD progression and personalizing treatment.International urology and nephrology · 2026Review
- Impact of CKD and COPD co-existence on mortality, vascular dementia, and Alzheimer's dementia; a comparative cohort study.BMC nephrology · 2026Observational
- The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations.BMC medicine · 2026Article
- Soft tissue calcifications in chronic kidney disease-beyond the vasculature.Pflugers Archiv : European journal of physiology · 2025Review
- Chronic Kidney Disease in Common Variable Immunodeficiency: a Multicenter Study.Journal of clinical immunology · 2025Observational
- Association Between Advanced Lung Cancer Inflammation Index and Mortality in US Adults with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Interorgan communication networks in the kidney-lung axis.Nature reviews. Nephrology · 2024Review
- Mutual Effects of Coincident Chronic Renal Failure and Chronic Obstructive Pulmonary Disease.Tanaffos · 2023Article
- Clinical characteristics of severe coronavirus disease 2019 patients with chronic obstructive pulmonary disease.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- Gender dimension in cardio-pulmonary continuum.Frontiers in cardiovascular medicine · 2022Review
- Distribution and impact of age in patients with implantable cardioverter-defibrillators regarding early complications and 1-year clinical outcome: results from the German Device Registry.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- Predictors of Renal Function Worsening in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Multicenter Observational Study.Nutrients · 2021Observational
- Exercise intolerance in kidney diseases: physiological contributors and therapeutic strategies.American journal of physiology. Renal physiology · 2021Review
- Diagnosis and Management of Pulmonary Hypertension in Patients With CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020Review
- Major comorbidities lead to the risk of adverse cardiovascular events in chronic obstructive pulmonary disease patients using inhaled long-acting bronchodilators: a case-control study.BMC pulmonary medicine · 2019Article
- Association of Extreme Heat Events With Hospital Admission or Mortality Among Patients With End-Stage Renal Disease.JAMA network open · 2019Article
- Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundChronic obstructive pulmonary disease (COPD) is associated with higher mortality in the general population. We studied the associations between COPD and death among chronic kidney disease (CKD) patients along with reporting cause-specific death data.
methodsWe included 56,960 patients with stages 3 and 4 CKD who were followed in a large health care system. Associations between COPD and all-cause mortality and various causes of death (respiratory deaths, cardiovascular deaths, malignancy-related deaths and deaths due to other reasons) were studied using the Cox proportional hazards and competing risk models.
resultsOut of 56,960 CKD patients, 4.7% (n = 2,667) had underlying COPD. Old age, presence of diabetes, hypertension, coronary artery disease, congestive heart failure, and smoking were associated with higher risk for COPD. During a median follow-up of 3.7 years, 15,969 patients died. After covariate adjustment, COPD was associated with a 41% increased risk (95% CI 1.31-1.52) for all-cause mortality, and fourfold increased risk (sub-hazard ratio 4.36, 95% CI 3.54-5.37) for respiratory-related deaths. In a sensitivity analysis that was performed by defining COPD as the use of relevant International Classification of Diseases-9 codes and medications used to treat COPD, similar results were noted.
conclusionsCOPD is associated with higher risk for death among those with CKD, and an underlying lung disease accounts for significant proportion of deaths. These data highlight the need for further prospective studies to understand the underlying mechanisms and potential interventions to improve outcomes in this population.
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