ArticleJournal of Alzheimer's disease : JAD2016
Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Association of vitamin D with risk of dementiaFrontiers in neurology · 2025Pooled it
- Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis.BMC neurology · 2019Pooled it
- Vitamin D concentration and risk of Alzheimer disease: A meta-analysis of prospective cohort studies.Medicine · 2019Pooled it
- Vitamin DNutrients · 2020Trial
- Association of Circulating Vitamin D in Midlife With Increased Tau-PET Burden in Dementia-Free Adults.Neurology open access · 2026Article
- Are long-lasting nonspecific symptoms related to vitamin D deficiency among older adults living in nursing homes?BMC geriatrics · 2025Article
- The role of serum vitamins in mediating the effect of neurodegenerative diseases on subcortical brain volume.The journal of prevention of Alzheimer's disease · 2025Article
- Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis.Nutrients · 2025Article
- Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels.Frontiers in nutrition · 2025Article
- The Moderating Effect of Serum Vitamin D on the Relationship between Beta-amyloid Deposition and Neurodegeneration.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Article
- Association between serum 25-hydroxyvitamin D3 level and cognitive impairment in older chronic kidney disease patients.Scientific reports · 2024Article
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
- Sex and race differences in the association of albumin with cognitive function in older adults.Brain and behavior · 2024Article
- The Potential Role of Vitamin D Supplementation in Cognitive Impairment Prevention.CNS & neurological disorders drug targets · 2024Review
- Vitamin D and focal brain atrophy in PD with non-dementia: a VBM study.Frontiers in human neuroscience · 2024Article
- Seasonal Variations in Vitamin D Levels and the Incident Dementia Among Older Adults Aged ≥60 Years in the UK Biobank.Journal of Alzheimer's disease reports · 2024Article
- Nephroprotective effect of vitamin D Against Levofloxacin-induced renal injury: an observational study.Journal of medicine and life · 2023Article
- Brain changes in neuroimaging of adult patients with vitamin D deficiency: systematic review protocol.BMJ open · 2023Article
- Vitamin D Status Over Time and Cognitive Function in Norwegian Older Adults: A Prospective Cohort of the HUNT Study.The journal of nutrition, health & aging · 2023Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundIdentifying nutrition- and lifestyle-based risk factors for cognitive impairment and dementia may aid future primary prevention efforts.
objectiveWe aimed to examine the association of serum vitamin D levels with incident all-cause dementia, clinically characterized Alzheimer's disease (AD), MRI markers of brain aging, and neuropsychological function.
methodsFramingham Heart Study participants had baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations measured between 1986 and 2001. Vitamin D status was considered both as a continuous variable and dichotomized as deficient (<10 ng/mL), or at the cohort-specific 20th and 80th percentiles. Vitamin D was related to the 9-year risk of incident dementia (n = 1663), multiple neuropsychological tests (n = 1291) and MRI markers of brain volume, white matter hyperintensities and silent cerebral infarcts (n = 1139).
resultsIn adjusted models, participants with vitamin D deficiency (n = 104, 8% of the cognitive sample) displayed poorer performance on Trail Making B-A (β= -0.03 to -0.05±0.02) and the Hooper Visual Organization Test (β= -0.09 to -0.12±0.05), indicating poorer executive function, processing speed, and visuo-perceptual skills. These associations remained when vitamin D was examined as a continuous variable or dichotomized at the cohort specific 20th percentile. Vitamin D deficiency was also associated with lower hippocampal volumes (β= -0.01±0.01) but not total brain volume, white matter hyperintensities, or silent brain infarcts. No association was found between vitamin D deficiency and incident all-cause dementia or clinically characterized AD.
conclusionsIn this large community-based sample, low 25(OH)D concentrations were associated with smaller hippocampal volume and poorer neuropsychological function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.