ArticleNature protocols2016
Study of in vivo catheter biofilm infections using pediatric central venous catheter implanted in rat.
Article in Nature protocols, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Intermittent antibiotic exposure of Escherichia coli biofilms drives resistance in catheter-associated infection models.NPJ biofilms and microbiomes · 2026Article
- Liquid-bodied antibiofilm robot with switchable viscoelastic response for biofilm eradication on complex surface topographies.Science advances · 2025Article
- Active Microrobots for Dual Removal of Biofilms via Chemical and Physical Mechanisms.ACS applied materials & interfaces · 2025Article
- A NewPharmaceutics · 2024Article
- A review on antimicrobial strategies in mitigating biofilm-associated infections on medical implants.Current research in microbial sciences · 2024Review
- Complete Genome Sequences of Bioluminescent Staphylococcus aureus Strains Xen31 and Xen36, Derived from Two Clinical Isolates.Microbiology resource announcements · 2023Article
- Fibrinolytic and antibiotic treatment of prosthetic vascular graft infections in a novel rat model.PloS one · 2023Article
- Review
- Effect of Biosynthesized Silver Nanoparticles on Bacterial Biofilm Changes inNanomaterials (Basel, Switzerland) · 2022Article
- Biofilm-forming microorganisms causing hospital-acquired infections from intravenous catheter: A systematic review.Current research in microbial sciences · 2022Article
- AssessingFrontiers in cellular and infection microbiology · 2022Article
- Speciality Grand Challenge for "Biofilms".Frontiers in cellular and infection microbiology · 2021Article
- Phenazine Antibiotic-Inspired Discovery of Bacterial Biofilm-Eradicating Agents.Chembiochem : a European journal of chemical biology · 2019Review
- Options and Limitations in Clinical Investigation of Bacterial Biofilms.Clinical microbiology reviews · 2018Review
- Anti-fouling strategies for central venous catheters.Cardiovascular diagnosis and therapy · 2017Review
- Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation.Antimicrobial agents and chemotherapy · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Venous access catheters used in clinics are prone to biofilm contamination, contributing to chronic and nosocomial infections. Although several animal models for studying device-associated biofilms were previously described, only a few detailed protocols are currently available. Here we provide a protocol using totally implantable venous access ports (TIVAPs) implanted in rats. This model recapitulates all phenomena observed in the clinic, and it allows bacterial biofilm development and physiology to be studied. After TIVAP implantation and inoculation with luminescent pathogens, in vivo biofilm formation can be monitored in situ, and biofilm biomass can be recovered from contaminated TIVAP and organs. We used this protocol to study host responses to biofilm infection, to evaluate preventive and curative antibiofilm strategies and to study fundamental biofilm properties. For this procedure, one should expect ∼3 h of hands-on time, including the implantation in one rat followed by in situ luminescence monitoring and bacterial load estimation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.