ArticleSmall (Weinheim an der Bergstrasse, Germany)2016
Quantitative Magnetic Separation of Particles and Cells Using Gradient Magnetic Ratcheting.
Article in Small (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Acoustic Streaming-Based 3D Cell Focusing and Plasma Separation.Micromachines · 2026Article
- Advances in Ultrasonic Rehabilitation.Sensors (Basel, Switzerland) · 2026Article
- Digital Magnetic Sorting for Fractionating Cell Populations with Variable Antigen Expression in Cell Therapy Process Development.Magnetochemistry (Basel, Switzerland) · 2024Article
- Immunomultiple PCR-based electrochemical and lateral flow strategy for the simultaneous detection of liver cancer tumor markers.Mikrochimica acta · 2023Article
- Numerical Studies on the Motions of Magnetically Tagged Cells Driven by a Micromagnetic Matrix.Micromachines · 2023Article
- Assessing Tumorigenicity in Stem Cell-Derived Therapeutic Products: A Critical Step in Safeguarding Regenerative Medicine.Bioengineering (Basel, Switzerland) · 2023Review
- Manipulation with sound and vibration: A review on the micromanipulation system based on sub-MHz acoustic waves.Ultrasonics sonochemistry · 2023Review
- Article
- Magnetic microparticle concentration and collection using a mechatronic magnetic ratcheting system.PloS one · 2021Article
- Past, Present, and Future of Affinity-based Cell Separation Technologies.Acta biomaterialia · 2020Review
- Magnetically driven microfluidics for isolation of circulating tumor cells.Cancer medicine · 2020Review
- Hybrid microfluidic sorting of rare cells based on high throughput inertial focusing and high accuracy acoustic manipulation.RSC advances · 2019Article
- Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting.Lab on a chip · 2018Article
- Continuous and Quantitative Purification of T-Cell Subsets for Cell Therapy Manufacturing Using Magnetic Ratcheting Cytometry.SLAS technology · 2018Article
- Sheathless inertial cell focusing and sorting with serial reverse wavy channel structures.Microsystems & nanoengineering · 2018Article
- Force-Mediating Magnetic Nanoparticles to Engineer Neuronal Cell Function.Frontiers in neuroscience · 2018Review
- Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly.Theranostics · 2017Article
- Inertial Focusing of Microparticles in Curvilinear Microchannels.Scientific reports · 2016Article
- Magnetic Nickel iron Electroformed Trap (MagNET): a master/replica fabrication strategy for ultra-high throughput (>100 mL h(-1)) immunomagnetic sorting.Lab on a chip · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Extraction of rare target cells from biosamples is enabling for life science research. Traditional rare cell separation techniques, such as magnetic activated cell sorting, are robust but perform coarse, qualitative separations based on surface antigen expression. A quantitative magnetic separation technology is reported using high-force magnetic ratcheting over arrays of magnetically soft micropillars with gradient spacing, and the system is used to separate and concentrate magnetic beads based on iron oxide content (IOC) and cells based on surface expression. The system consists of a microchip of permalloy micropillar arrays with increasing lateral pitch and a mechatronic device to generate a cycling magnetic field. Particles with higher IOC separate and equilibrate along the miropillar array at larger pitches. A semi-analytical model is developed that predicts behavior for particles and cells. Using the system, LNCaP cells are separated based on the bound quantity of 1 μm anti-epithelial cell adhesion molecule (EpCAM) particles as a metric for expression. The ratcheting cytometry system is able to resolve a ±13 bound particle differential, successfully distinguishing LNCaP from PC3 populations based on EpCAM expression, correlating with flow cytometry analysis. As a proof-of-concept, EpCAM-labeled cells from patient blood are isolated with 74% purity, demonstrating potential toward a quantitative magnetic separation instrument.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.