Evidence map›Paper›PMID 26890480›Full record

ArticleAdvanced healthcare materials2016

Poly(Limonene Thioether) Scaffold for Tissue Engineering.

Kristin M Fischer, Kathy Ye Morgan, Keith Hearon, Demetra Sklaviadis, Zachary L Tochka, Owen S Fenton, Daniel G Anderson, Robert Langer, Lisa E Freed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristin M FischerHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Kathy Ye MorganHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Keith HearonHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Demetra SklaviadisHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Zachary L TochkaHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Owen S FentonHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Daniel G AndersonHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Robert LangerHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Lisa E FreedHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Funding

Scalable Units for Building Vascularized Cardiac GraftR01HL107503 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FREED, LISA E · 2011 to 2015
$2.7M
NHLBI NIH HHS R01 HL107503NHLBI NIH HHS R01-HL107503
6 · The paper itself

Abstract

A photocurable thiol-ene network polymer, poly(limonene thioether) (PLT32o), is synthesized, characterized, fabricated into tissue engineering scaffolds, and demonstrated in vitro and in vivo. Micromolded PLT32o grids exhibit compliant, elastomeric mechanical behavior similar to grids made of poly(glycerol sebacate) (PGS), an established biomaterial. Multilayered PL32o scaffolds with regular, geometrically defined pore architectures support heart cell seeding and culture in a manner similar to multilayered PGS scaffolds. Subcutaneous implantation of multilayered PLT32o scaffolds with cultured heart cells provides long-term 3D structural support and retains the exogenous cells, whereas PGS scaffolds lose both their structural integrity and the exogenous cells over 31 d in vivo. PLT32o membrane implants retain their dry mass, whereas PGS implants lose 70 percent of their dry mass by day 31. Macrophages are initially recruited to PLT32o and PGS membrane implants but are no longer present by day 31. Facile synthesis and processing in combination with the capability to support heart cells in vitro and in vivo suggest that PLT32o can offer advantages for tissue engineering applications where prolonged in vivo maintenance of 3D structural integrity and elastomeric mechanical behavior are required.

Indexed as

AnimalsCells, CulturedCyclohexane MonoterpenesCyclohexenesLimoneneMiceMonoterpenesMyocytes, CardiacPolymersRats, NudeTerpenesTime FactorsTissue EngineeringTissue ScaffoldsCyclohexane MonoterpenesCyclohexenesLimoneneMonoterpenespoly(limonene thioether)PolymersTerpenesbiomaterialheart cellin vivothiol-ene polymer

Identifiers

PMID26890480
PMCPMC4828277

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.