ArticleAmerican journal of respiratory and critical care medicine2016
Latent Tuberculosis Infection Test Agreement in the National Health and Nutrition Examination Survey.
Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Trends and projection of pulmonary tuberculosis incidence in Hubei Province, china: an age‒period‒cohort modeling study.BMC infectious diseases · 2025Article
- Association between systemic immune-inflammation index and latent tuberculosis infection: a cross-sectional study.Frontiers in medicine · 2025Article
- Examining Test Cutoffs to Optimize Diagnosis of Latent Tuberculosis Infection in People Born Outside the United States.Annals of the American Thoracic Society · 2023Article
- Comparison of three tests for latent tuberculosis infection in high-risk people in the USA: an observational cohort study.The Lancet. Infectious diseases · 2022Observational
- Self-reported Engagement in Care among U.S. Residents with Latent Tuberculosis Infection: 2011-2012.Annals of the American Thoracic Society · 2021Article
- Challenges in LTBI care in the United States identified using a nationwide TB medical consultation database.Public health action · 2021Article
- Estimated Latent Tuberculosis Infection Prevalence and Tuberculosis Reactivation Rates Among Non-U.S.-Born Residents in the United States, from the 2011-2012 National Health and Nutrition Examination Survey.Journal of immigrant and minority health · 2021Article
- Optimizing the Design of Latent Tuberculosis Treatment Trials: Insights from Mathematical Modeling.American journal of respiratory and critical care medicine · 2020Article
- Comparison of the QuantiFERON-TB and tuberculin skin test for detection of latent tuberculosis infection in cancer patients in a developing country.ERJ open research · 2019Article
- Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Sex differences in tuberculosis.Seminars in immunopathology · 2019Review
- Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011-2012.Infection and drug resistance · 2019Article
- Performance of the QuantiFERONThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018Article
- Glycemic Control and the Prevalence of Tuberculosis Infection: A Population-based Observational Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Observational
- Back pain and oedematous Schmorl node: a diagnostic dilemma.BMJ case reports · 2017Article
- The Replacement Principle of Tuberculosis. Why Prevention Matters.American journal of respiratory and critical care medicine · 2016Article
- Tuberculosis screening in multiple sclerosis: effect of disease-modifying therapies and lymphopenia on the prevalence of indeterminate TB screening results in the clinical setting.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
rationaleLatent tuberculosis infection (LTBI) test discordance is poorly understood.
objectivesTo determine the frequency and predictors of tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube test (QFT) discordance in the U.S.
methodsWe analyzed data from a representative sample of the U.S. population ages 6 years and older who participated in the 2011-2012 National Health and Nutrition Examination Survey. We determined prevalence estimates of test positivity, calculated test agreement and kappa statistics, and performed multivariable logistic regression to determine predictors of discordance. MEASUREMENTS AND MAIN
resultsLTBI prevalence among the U.S. born ranged from 0.6% to 2.8%, depending on how LTBI was defined, with test agreement 97.0% and kappa 0.27 (95% confidence interval, 0.18-0.36). Prevalence among the foreign born ranged from 9.1% to 20.3%, depending on how LTBI was defined, with test agreement 81.6% and kappa 0.38 (95% confidence interval, 0.33-0.44). TST(+)/QFT(-) discordance was associated with age, male sex, black race, Mexican-American ethnicity, previous TB exposure, and past LTBI treatment in U.S.-born participants, but only with higher lymphocyte count in foreign-born participants. TST(-)/QFT(+) discordance was associated with older age, previous TB exposure, and past LTBI treatment in U.S.-born participants and with older age, male sex, and past LTBI treatment in foreign-born participants.
conclusionsIn the largest population-based sample of concurrently performed TST and QFT tests in a low tuberculosis incidence population, prevalence estimates depended heavily on how LTBI was defined and test agreement was only fair. We identified several predictors of discordance warranting further study.
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