Evidence map›Paper›PMID 26890472›Full record

Trial reportThe New England journal of medicine2016

Long-Term Results of Stenting versus Endarterectomy for Carotid-Artery Stenosis.

Thomas G Brott, George Howard, Gary S Roubin, James F Meschia, Ariane Mackey, William Brooks, Wesley S Moore, Michael D Hill, Vito A Mantese, Wayne M Clark and 10 more

4 registry-linked trialsOpen access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The New England journal of medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 229 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
229citing papers in PubMed, 6 pooled it
76.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03507374 early_phase1terminatedstarted 2018, after this paper: background citation

PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis

Ran2018Enrolled20Registered outcomes5Posted comparisons0ConditionsIntracranial Atherosclerosis, Intraplaque Hemorrhage, StrokeArmsAlirocumab, Placebo
PMID 17312027PMID 25307297PMID 25453443PMID 24135208PMID 25790886PMID 25854637PMID 23988640PMID 23463579PMID 23404720PMID 22872053PMID 21958949PMID 21536995other papers from this trial
Open the trial in the graph
NCT00004732 nacompletednot on this map

Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2000 to 2016Enrolled2,502ConditionsAtherosclerosis, Stroke, Carotid Stenosis, Cerebral InfarctionArmsCarotid Endarterectomy (CEA), Carotid Artery Stenting (CAS)
NCT04271033 naunknown statusnot on this map

Long-term Outcomes of MicroNet-covered Stent Routine Use for Stroke Prevention in Symptomatic and Increased-risk Asymptomatic Carotid Stenosis Patients Requiring Revascularization by Neurovascular Team Decision: PARADIGM-EXTEND

TypeinterventionalSponsorJohn Paul II Hospital, KrakowRan2015 to 2026Enrolled550ConditionsCarotid Artery DiseasesArmsCarotid Artery Stenting
NCT05907629 recruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

TypeobservationalSponsorYale UniversityRan2024 to 2029Enrolled300ConditionsStroke, Intracranial Atherosclerotic Stenosis (ICAS)ArmsMRI
3 · Its place in the literature

Who cites it

229 citing papers in PubMed, 6 syntheses or guidelines pooled it, 713 citations in OpenAlex.

  1. Pooled it
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  7. Trial
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  9. Carotid artery stenting without embolic protection: A randomized multicenter trial (the CASWEP trial).Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023
    Trial
  10. Trial
  11. Trial
  12. Trial
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  17. Diagnostic Performance of Duplex Ultrasonography in Post-Radiation Common Carotid Artery Stenosis: A Cross-Sectional Validation Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Article
  18. Article
  19. Article
  20. Observational

169 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Thomas G BrottFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
George HowardFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Gary S RoubinFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
James F MeschiaFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Ariane MackeyFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
William BrooksFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Wesley S MooreFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Michael D HillFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Vito A ManteseFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Wayne M ClarkFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Carlos H TimaranFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Donald HeckFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Pierre P LeimgruberFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Alice J SheffetFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Virginia J HowardFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Seemant ChaturvediFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Brajesh K LalFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Jenifer H VoeksFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
Robert W HobsonFrom the Mayo Clinic, Jacksonville, FL (T.G.B., J.F.M.); the University of Alabama at Birmingham (G.H., V.J.H.) and Cardiovascular Associates of the Southeast (G.S.R.) - both in Birmingham; Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC (A.M.), and the University of Calgary, Calgary, AB (M.D.H.) - both in Canada; Baptist Health Lexington, KY (W.B.); the University of California, Los Angeles, Los Angeles (W.S.M.); Mercy Hospital St. Louis, St. Louis (V.A.M.); Oregon Health and Science University, Portland (W.M.C.); the University of Texas Southwestern Medical Center, Dallas (C.H.T); Novant Health Clinical Research, Winston-Salem, NC (D.H.); the Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA (P.P.L.); Rutgers New Jersey Medical School, Newark (A.J.S., R.W.H.); the University of Miami Miller School of Medicine, Miami (S.C.); the University of Maryland Medical Center, Baltimore (B.K.L.); and the Medical University of South Carolina, Charleston (J.H.V.).
CREST Investigators
University of Maryland, Baltimore · USUniversity of Calgary · CAMercy Hospital · USOregon Health & Science University · USRutgers New Jersey Medical SchoolUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of Miami · US

Funding

Carotid Revascularization Endarterectomy vs Stenting TrialR01NS038384 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BROTT, THOMAS G · 1999 to 2010
$40.7M
Carotid Revascularization Endarterectomy vs. Stenting Trial: Long Term Follow-upU01NS038384 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BROTT, THOMAS G, SHEFFET, ALICE J · 2011 to 2016
$15.4M
NINDS NIH HHS R01 NS038384NINDS NIH HHS U01 NS038384NINDS NIH HHS U01 NS038384-11
6 · The paper itself

Abstract

backgroundIn the Carotid Revascularization Endarterectomy versus Stenting Trial, we found no significant difference between the stenting group and the endarterectomy group with respect to the primary composite end point of stroke, myocardial infarction, or death during the periprocedural period or any subsequent ipsilateral stroke during 4 years of follow-up. We now extend the results to 10 years.

methodsAmong patients with carotid-artery stenosis who had been randomly assigned to stenting or endarterectomy, we evaluated outcomes every 6 months for up to 10 years at 117 centers. In addition to assessing the primary composite end point, we assessed the primary end point for the long-term extension study, which was ipsilateral stroke after the periprocedural period.

resultsAmong 2502 patients, there was no significant difference in the rate of the primary composite end point between the stenting group (11.8%; 95% confidence interval [CI], 9.1 to 14.8) and the endarterectomy group (9.9%; 95% CI, 7.9 to 12.2) over 10 years of follow-up (hazard ratio, 1.10; 95% CI, 0.83 to 1.44). With respect to the primary long-term end point, postprocedural ipsilateral stroke over the 10-year follow-up occurred in 6.9% (95% CI, 4.4 to 9.7) of the patients in the stenting group and in 5.6% (95% CI, 3.7 to 7.6) of those in the endarterectomy group; the rates did not differ significantly between the groups (hazard ratio, 0.99; 95% CI, 0.64 to 1.52). No significant between-group differences with respect to either end point were detected when symptomatic patients and asymptomatic patients were analyzed separately.

conclusionsOver 10 years of follow-up, we did not find a significant difference between patients who underwent stenting and those who underwent endarterectomy with respect to the risk of periprocedural stroke, myocardial infarction, or death and subsequent ipsilateral stroke. The rate of postprocedural ipsilateral stroke also did not differ between groups. (Funded by the National Institutes of Health and Abbott Vascular Solutions; CREST ClinicalTrials.gov number, NCT00004732.).

Indexed as

Endarterectomy, CarotidStentsAdultAgedAged, 80 and overAngioplastyCarotid StenosisFemaleFollow-Up StudiesHumansLife ExpectancyMaleMiddle AgedMyocardial InfarctionRiskStroke

Identifiers

PMID26890472
PMCPMC4874663
OpenAlexW2332609836

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.