ArticleEmerging infectious diseases2016
Underestimation of Invasive Meningococcal Disease in Italy.
Article in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Invasive Meningococcal Disease on the Workplaces: a systematic review.Acta bio-medica : Atenei Parmensis · 2017Pooled it
- Invasive meningococcal disease in South-Eastern European countries: Do we need to revise vaccination strategies?Human vaccines & immunotherapeutics · 2024Article
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- Epidemiological study of bacterial meningitis in Tunisian children, beyond neonatal age, using molecular methods: 2014-2017.African health sciences · 2020Article
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- Invasive meningococcal disease in Italy: from analysis of national data to an evidence-based vaccination strategy.Journal of preventive medicine and hygiene · 2020Article
- Recurrent invasive meningococcal infections - quantifying the risk, Germany, 2002 to 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- [Health Technology Assessment of meningococcal B vaccine (TrumenbaJournal of preventive medicine and hygiene · 2019Article
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- Is primary meningococcal arthritis in children more frequent than we expect? Two pediatric case reports revealed by molecular test.BMC infectious diseases · 2018Article
- Do Tuscan people adhere to meningococcal C vaccination during an emergency campaign?Journal of preventive medicine and hygiene · 2018Article
- Interconnected clusters of invasive meningococcal disease due toEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
- Article
- [Advances in diagnostic microbiology : Opportunities and limitations].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Review
- Correia Repeat Enclosed Elements and Non-Coding RNAs in the Neisseria Species.Microorganisms · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowing the incidence of invasive meningococcal disease (IMD) is essential for planning appropriate vaccination policies. However, IMD may be underestimated because of misdiagnosis or insufficiently sensitive laboratory methods. Using a national molecular surveillance register, we assessed the number of cases misdiagnosed and diagnoses obtained postmortem with real-time PCR (rPCR), and we compared sensitivity of rPCR versus culture-based testing. A total of 222 IMD cases were identified: 11 (42%) of 26 fatal cases had been misdiagnosed or undiagnosed and were reclassified as IMD after rPCR showed meningococcal DNA in all available specimens taken postmortem. Of the samples tested with both rPCR and culture, 58% were diagnosed by using rPCR alone. The underestimation factor associated with the use of culture alone was 3.28. In countries such as Italy, where rPCR is in limited use, IMD incidence may be largely underestimated; thus, assessments of benefits of meningococcal vaccination may be prone to error.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.