ArticleCell cycle (Georgetown, Tex.)2016
Overexpression of cyclin D1 induces the reprogramming of differentiated epidermal cells into stem cell-like cells.
Article in Cell cycle (Georgetown, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
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- HC-HA/PTX3 from amniotic membrane reprograms human corneal fibroblasts to neural crest progenitors by switching from canonical to noncanonical TGFβ signaling.Stem cell research & therapy · 2026Article
- Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances.Exploration (Beijing, China) · 2026Review
- Spatiotemporal dynamics of mammalian wound healing.Cell discovery · 2026Review
- Long-Term Hypoxia Upregulates Wnt and TGFβ1 Signaling in Eccrine Sweat Gland Cells In Vitro.International journal of molecular sciences · 2025Article
- Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets.Biomedicines · 2022Review
- Gene identification and functional analysis of a D-type cyclin (CCND2) in freshwater pearl mussel (Hyriopsis cumingii).Molecular biology reports · 2022Article
- Review
- Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells.Environmental health perspectives · 2021Article
- GDF-5 promotes epidermal stem cells proliferation via Foxg1-cyclin D1 signaling.Stem cell research & therapy · 2021Article
- Reprogramming of Keratinocytes as Donor or Target Cells Holds Great Promise for Cell Therapy and Regenerative Medicine.Stem cell reviews and reports · 2019Review
- Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis.Cell death & disease · 2018Article
- Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes.BMC genomics · 2018Article
- GSK3β inhibitor promotes myelination and mitigates muscle atrophy after peripheral nerve injury.Neural regeneration research · 2018Article
- Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review).Molecular medicine reports · 2017Review
- Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that Wnt/β-catenin is critical for dedifferentiation of differentiated epidermal cells. Cyclin D1 (CCND1) is a β-catenin target gene. In this study, we provide evidence that overexpression of CCND1 induces reprogramming of epidermal cells into stem cell-like cells. After introducing CCND1 gene into differentiated epidermal cells, we found that the large flat-shaped cells with a small nuclear-cytoplasmic ratio changed into small round-shaped cells with a large nuclear-cytoplasmic ratio. The expressions of CK10, β1-integrin, Oct4 and Nanog in CCND1 induced cells were remarkably higher than those in the control group (P < 0.01). In addition, the induced cells exhibited a high colony-forming ability and a long-term proliferative potential. When the induced cells were implanted into a wound of laboratory animal model, the wound healing was accelerated. These results suggested that overexpression of CCND1 induced the reprogramming of differentiated epidermal cells into stem cell-like cells. This study may also offer a new approach to yield epidermal stem cells for wound repair and regeneration.
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