Evidence map›Paper›PMID 26890149›Full record

ArticleThe Analyst2016

Nanoparticles of gadolinium-incorporated Prussian blue with PEG coating as an effective oral MRI contrast agent for gastrointestinal tract imaging.

Vindya S Perera, Guojun Chen, Qing Cai, Songping D Huang

Abstract read
In one paragraph

Article in The Analyst, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Advances in macrophage-targeting nanoparticles for the diagnosis and treatment of inflammatory bowel disease.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vindya S PereraDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.
Guojun ChenDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.
Qing CaiDepartment of Radiology, Suzhou University-Affiliated Hospital, Nanjing Medical University, Suzhou, 215123, Jiangsu Province, China. caiq1202@163.com.
Songping D HuangDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.

Funding

Prussian Blue Nanoparticles as Cellular T1 MRI Contrast AgentsR21CA143408 · NCI · KENT STATE UNIVERSITY · PI HUANG, SONGPING D · 2011 to 2013
$501k
NCI NIH HHS 1R21CA143408-01A1NCI NIH HHS R21 CA143408
6 · The paper itself

Abstract

Biocompatible nanoparticles of gadolinium-incorporated Prussian blue with the empirical formula K(0.94)Gd(0.02)Fe[Fe(CN)6] exhibit extremely high stability against the release of Gd(3+) and CN(-) ions under the acidic conditions similar to stomach juice. The high r1 relaxivity, low cytotoxicity and the ability of such nanoparticles to penetrate the cell membrane suggest that this coordination-polymer structural platform offers a unique opportunity for developing the next generation of T1-weighted oral cellular MRI probes for the early detection of tumors in the gastrointestinal tract.

Indexed as

AnimalsBiological TransportContrast MediaDrug StabilityFerrocyanidesGadoliniumGastrointestinal TractHT29 CellsHumansMagnetic Resonance ImagingNanoparticlesPolyethylene GlycolsRabbitsContrast Mediaferric ferrocyanideFerrocyanidesGadoliniumPolyethylene Glycols

Identifiers

PMID26890149
PMCPMC4922917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.