Evidence map›Paper›PMID 26890076›Full record

ArticleAngewandte Chemie (International ed. in English)2016

Glycation Reactivity of a Quorum-Sensing Signaling Molecule.

Kyoji Tsuchikama, Major Gooyit, Tyler L Harris, Jie Zhu, Daniel Globisch, Gunnar F Kaufmann, Kim D Janda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kyoji TsuchikamaThe Skaggs Institute for Chemical Biology and Departments of Chemistry, Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Major GooyitThe Skaggs Institute for Chemical Biology and Departments of Chemistry, Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Tyler L HarrisThe Skaggs Institute for Chemical Biology and Departments of Chemistry, Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Jie ZhuThe Skaggs Institute for Chemical Biology and Departments of Chemistry, Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Daniel GlobischThe Skaggs Institute for Chemical Biology and Departments of Chemistry, Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Gunnar F KaufmannThe Skaggs Institute for Chemical Biology and Departments of Chemistry, Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Kim D JandaThe Skaggs Institute for Chemical Biology and Departments of Chemistry, Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. kdjanda@scripps.edu.
Scripps Research Institute · US

Funding

Chemical Strategies to Manipulate A1-2 Signaling in Bacterial PathogensR01AI077644 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 2010 to 2014
$2.3M
NIAID NIH HHS AI077644NIAID NIH HHS R01 AI077644
6 · The paper itself

Abstract

Reported herein is that (4S)-4,5-dihydroxy-2,3-pentanedione (DPD) can undergo a previously undocumented non-enzymatic glycation reaction. Incubation of DPD with viral DNA or the antibiotic gramicidin S resulted in significant biochemical alterations. A protein-labeling method was consequently developed that facilitated the identification of unrecognized glycation targets of DPD in a prokaryotic system. These results open new avenues toward tracking and understanding the fate and function of the elusive quorum-sensing signaling molecule.

Indexed as

Quorum SensingSignal TransductionDNAGlucosePentanes4,5-dihydroxy-2,3-pentanedioneDNAGlucosePentanesfluorescent probesglycationprotein modificationsproteomicsquorum sensing

Identifiers

PMID26890076
PMCPMC4965832
OpenAlexW2287278175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.