ArticleJournal of the American Geriatrics Society2016
Antipsychotic Use in Hospitalized Adults: Rates, Indications, and Predictors.
Article in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Exploring Antipsychotic Use for Delirium Management in Adults in Hospital, Sub-Acute Rehabilitation and Aged Care Settings: A Systematic Literature Review.Drugs & aging · 2024Pooled it
- Reconsidering antipsychotic-associated dysphagia in acute heart failure: implications for multidisciplinary risk management.Heart and vessels · 2026Article
- Antipsychotic use and dysphagia risk in acute heart failure: a prospective cohort study.Heart and vessels · 2026Article
- Trends in Antipsychotic Drug Use in the United States, 2000-2016.Pharmacy (Basel, Switzerland) · 2026Article
- Prescribing and deprescribing of atypical antipsychotics in older multimorbid patients.BMC geriatrics · 2025Article
- Monotherapy Versus Combination Therapy in Agitation Management in the Intensive Care Unit: A Narrative Review.Cureus · 2025Review
- Pattern and Associated Factors of Benzodiazepine Discontinuation Among Older Adults Following Hospitalization.Journal of the American Geriatrics Society · 2025Article
- Initiation and Persistence of Antipsychotic Medications at Hospital Discharge Among Community-Dwelling Veterans With Dementia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- The Risk of Venous Thromboembolism Events Resulting in Hospitalization following Exposure to Antipsychotic Medication in Pre-Disposed Adult Patients.Innovations in pharmacy · 2024Article
- Antipsychotic Medication Use Among Newly Admitted Long-term Care Residents During the COVID-19 Pandemic in Canada.Health services insights · 2024Article
- Trends in use of antipsychotics and psychoactive drugs in older patients after major surgery.Journal of the American Geriatrics Society · 2023Article
- Prescribing pattern of antipsychotics for patients with schizophrenia using the total daily dose online tool.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Article
- Acute Antipsychotic Use and Presence of Dysphagia Among Older Veterans with Heart Failure.Journal of the American Medical Directors Association · 2023Article
- Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.Annals of internal medicine · 2023Article
- Antipsychotic medications for older adults with delirium admitted to hospital.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- New psychotropic medication use among Medicare beneficiaries with dementia after hospital discharge.Journal of the American Geriatrics Society · 2023Article
- Antipsychotic Medication Use Among Older Adults Following Infection-Related Hospitalization.JAMA network open · 2023Article
- Prescribing decision making by medical residents on night shifts: A qualitative study.Medical education · 2022Article
- New Antipsychotic Prescribing Continued into Skilled Nursing Facilities Following a Heart Failure Hospitalization: a Retrospective Cohort Study.Journal of general internal medicine · 2022Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo investigate patterns and predictors of use of antipsychotics in hospitalized adults.
designRetrospective cohort study.
settingAcademic medical center.
participantsIndividuals aged 18 and older hospitalized from August 2012 to August 2013, excluding those admitted to obstetrics and gynecology or psychiatry or with a psychotic disorder. MEASUREMENTS: Use was ascertained from pharmacy charges. Potentially excessive dosing was defined using guidelines for long-term care facilities. A review of 100 records was performed to determine reasons for use.
resultsThe cohort included 17,775 admissions with a median age 64; individuals could have been admitted more than once during the study period. Antipsychotics were used in 9%, 55% of which were initiations. The most common reasons for initiation were delirium (53%) and probable delirium (12%). Potentially excessive dosing occurred in 16% of admissions exposed to an antipsychotic. Of admissions with antipsychotic initiation, 26% were discharged on these medications. Characteristics associated with initiation included age 75 and older (relative risk (RR) = 1.4, 95% confidence interval (CI) = 1.2-1.7), male sex (RR = 1.2, 95% CI = 1.1-1.4), black race (RR = 0.8, 95% CI = 0.6-0.96), delirium (RR = 4.8, 95% CI = 4.2-5.7), dementia (RR = 2.1, 95% CI = 1.7-2.6), admission to a medical service (RR = 1.2, 95% CI = 1.1-1.4), intensive care unit stay (RR = 2.1, 95% CI = 1.8-2.4), and mechanical ventilation (RR = 2.0, 95% CI = 1.7-2.4). In individuals who were initiated on an antipsychotic, characteristics associated with discharge on antipsychotics were age 75 and older (RR = 0.6, 95% CI = 0.4-0.7), discharge to any location other than home (RR = 2.5, 95% CI = 1.8-3.3), and class of in-hospital antipsychotic exposure (RR = 1.6, 95% CI = 1.1-2.3 for atypical vs typical; RR = 2.7, 95% CI = 1.9-3.8 for both vs typical).
conclusionAntipsychotic initiation and use were common during hospitalization, most often for delirium, and individuals were frequently discharged on these medications. Several predictors of use on discharge were identified, suggesting potential targets for decision support tools that would be used to prompt consideration of ongoing necessity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.