ArticleNeuron2016
Membrane Potential Dynamics of CA1 Pyramidal Neurons during Hippocampal Ripples in Awake Mice.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Designer indicators for two-photon recording of subthreshold voltage dynamics.Nature methods · 2026Article
- Designer indicators for two-photon recording of subthreshold voltage dynamics.bioRxiv : the preprint server for biology · 2026Article
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- Systems memory consolidation during sleep: oscillations, neuromodulators, and synaptic remodeling.BMB reports · 2025Review
- Electroanatomy of hippocampal activity patterns: theta, gamma waves, sharp wave-ripples, and dentate spikes.Frontiers in behavioral neuroscience · 2025Article
- Sleep microstructure organizes memory replay.Nature · 2025Article
- Article
- Functional architecture of intracellular oscillations in hippocampal dendrites.Nature communications · 2024Article
- Functional architecture of intracellular oscillations in hippocampal dendrites.bioRxiv : the preprint server for biology · 2024Article
- Intra-ripple frequency accommodation in an inhibitory network model for hippocampal ripple oscillations.PLoS computational biology · 2024Article
- Postnatal Maturation of Membrane Potential Dynamics duringThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Optogenetics reveals paradoxical network stabilizations in hippocampal CA1 and CA3.Current biology : CB · 2023Article
- Article
- Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network.Current biology : CB · 2023Article
- Calbindin-Expressing CA1 Pyramidal Neurons Encode Spatial Information More Efficiently.eNeuro · 2023Article
- Local neuronal excitation and global inhibition during epileptic fast ripples in humans.Brain : a journal of neurology · 2023Article
- Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo.Nature communications · 2022Article
- Article
- Somatic Depolarization Enhances Hippocampal CA1 Dendritic Spike Propagation and Distal Input-Driven Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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4 authors.
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Abstract
Ripples are high-frequency oscillations associated with population bursts in area CA1 of the hippocampus that play a prominent role in theories of memory consolidation. While spiking during ripples has been extensively studied, our understanding of the subthreshold behavior of hippocampal neurons during these events remains incomplete. Here, we combine in vivo whole-cell and multisite extracellular recordings to characterize the membrane potential dynamics of identified CA1 pyramidal neurons during ripples. We find that the subthreshold depolarization during ripples is uncorrelated with the net excitatory input to CA1, while the post-ripple hyperpolarization varies proportionately. This clarifies the circuit mechanism keeping most neurons silent during ripples. On a finer timescale, the phase delay between intracellular and extracellular ripple oscillations varies systematically with membrane potential. Such smoothly varying delays are inconsistent with models of intracellular ripple generation involving perisomatic inhibition alone. Instead, they suggest that ripple-frequency excitation leading inhibition shapes intracellular ripple oscillations.
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